PHISP_07250 protein (Phialosimplex sp. HF37)

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second shell of interactors

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Edges:

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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[Homology]

Score

PHISP_07250

C-8 sterol isomerase. (249 aa)

Predicted Functional Partners:

PHISP_05729

0.996

PHISP_03173

0.992

PHISP_05153

0.981

PHISP_05491

0.961

PHISP_06066

0.958

PHISP_05957

0.958

PHISP_01115

0.958

PHISP_04344

0.944

PHISP_04631

0.944

PHISP_03376

0.941

Your Current Organism:

Phialosimplex sp. HF37

NCBI taxonomy Id: 1960876
Other names: P. sp. HF37

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PHISP_01115	PHISP_03173	A0A3M2TDX2	A0A3M2T833	Ergosterol biosynthesis protein.	Sterol 24-c-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.	0.924
PHISP_01115	PHISP_03376	A0A3M2TDX2	A0A3M2T7U6	Ergosterol biosynthesis protein.	Reductase.	0.929
PHISP_01115	PHISP_04344	A0A3M2TDX2	A0A3M2T540	Ergosterol biosynthesis protein.	Sterol desaturase; Belongs to the sterol desaturase family.	0.889
PHISP_01115	PHISP_04631	A0A3M2TDX2	A0A3M2T585	Ergosterol biosynthesis protein.	C-4 methylsterol oxidase; Belongs to the sterol desaturase family.	0.889
PHISP_01115	PHISP_05153	A0A3M2TDX2	A0A3M2T2D4	Ergosterol biosynthesis protein.	C-4 methylsterol oxidase; Belongs to the sterol desaturase family.	0.963
PHISP_01115	PHISP_05491	A0A3M2TDX2	A0A3M2T1E8	Ergosterol biosynthesis protein.	Squalene.	0.576
PHISP_01115	PHISP_05729	A0A3M2TDX2	A0A3M2T1F8	Ergosterol biosynthesis protein.	Sterol 24-C-methyltransferase; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.	0.956
PHISP_01115	PHISP_05957	A0A3M2TDX2	A0A3M2T0T9	Ergosterol biosynthesis protein.	C-3 sterol dehydrogenase.	0.960
PHISP_01115	PHISP_06066	A0A3M2TDX2	A0A3M2SZR1	Ergosterol biosynthesis protein.	Fatty acid hydroxylase superfamily; Belongs to the sterol desaturase family.	0.959
PHISP_01115	PHISP_07250	A0A3M2TDX2	A0A3M2SWC2	Ergosterol biosynthesis protein.	C-8 sterol isomerase.	0.958
PHISP_03173	PHISP_01115	A0A3M2T833	A0A3M2TDX2	Sterol 24-c-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.	Ergosterol biosynthesis protein.	0.924
PHISP_03173	PHISP_03376	A0A3M2T833	A0A3M2T7U6	Sterol 24-c-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.	Reductase.	0.871
PHISP_03173	PHISP_04344	A0A3M2T833	A0A3M2T540	Sterol 24-c-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.	Sterol desaturase; Belongs to the sterol desaturase family.	0.844
PHISP_03173	PHISP_04631	A0A3M2T833	A0A3M2T585	Sterol 24-c-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.	C-4 methylsterol oxidase; Belongs to the sterol desaturase family.	0.844
PHISP_03173	PHISP_05153	A0A3M2T833	A0A3M2T2D4	Sterol 24-c-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.	C-4 methylsterol oxidase; Belongs to the sterol desaturase family.	0.844
PHISP_03173	PHISP_05491	A0A3M2T833	A0A3M2T1E8	Sterol 24-c-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.	Squalene.	0.487
PHISP_03173	PHISP_05729	A0A3M2T833	A0A3M2T1F8	Sterol 24-c-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.	Sterol 24-C-methyltransferase; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.	0.876
PHISP_03173	PHISP_05957	A0A3M2T833	A0A3M2T0T9	Sterol 24-c-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.	C-3 sterol dehydrogenase.	0.846
PHISP_03173	PHISP_06066	A0A3M2T833	A0A3M2SZR1	Sterol 24-c-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.	Fatty acid hydroxylase superfamily; Belongs to the sterol desaturase family.	0.956
PHISP_03173	PHISP_07250	A0A3M2T833	A0A3M2SWC2	Sterol 24-c-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.	C-8 sterol isomerase.	0.992

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Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.787

expected number of edges:

14

PPI enrichment p-value:

0.0197

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001963

Synaptic transmission, dopaminergic

3 of 14

2.59

1.81

0.00046

GO:0042417

Dopamine metabolic process

3 of 17

2.51

1.78

0.00051

GO:0098810

Neurotransmitter reuptake

3 of 18

2.48

1.77

0.00051

GO:0015844

Monoamine transport

3 of 18

2.48

1.77

0.00051

GO:0007212

Dopamine receptor signaling pathway

3 of 21

2.42

1.76

0.00051

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035240

Dopamine binding

3 of 6

2.96

2.48

3.07e-05

GO:0001591

Dopamine neurotransmitter receptor activity, coupled via Gi/Go

2 of 3

3.08

1.42

0.0027

GO:0015378

Sodium:chloride symporter activity

2 of 9

2.61

1.12

0.0090

GO:0008504

Monoamine transmembrane transporter activity

2 of 9

2.61

1.12

0.0090

GO:0005326

Neurotransmitter transmembrane transporter activity

2 of 14

2.42

1.04

0.0122

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

3 of 29

2.28

1.6

0.00094

GO:0036477

Somatodendritic compartment

5 of 589

1.19

0.87

0.0046

GO:0030425

Dendrite

4 of 436

1.22

0.8

0.0104

GO:0098797

Plasma membrane protein complex

4 of 456

1.2

0.79

0.0104

GO:0030424

Axon

4 of 477

1.18

0.78

0.0105

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:26528222

(2015) Genetic influences on insight problem solving: the role of catechol-O-methyltransferase (COMT) gene polymorphisms.

3 of 5

3.04

2.56

2.23e-05

PMID:34072960

(2021) Understanding Emotions: Origins and Roles of the Amygdala.

3 of 12

2.66

2.19

9.02e-05

PMID:29579395

(2018) Polygenic Risk Scores in Clinical Psychology: Bridging Genomic Risk to Individual Differences.

3 of 16

2.53

2.09

0.00013

PMID:33343403

(2020) The Autism Palette: Combinations of Impairments Explain the Heterogeneity in ASD.

2 of 6

2.78

1.22

0.0062

PMID:31616587

(2019) The dopamine receptor D5 gene shows signs of independent erosion in toothed and baleen whales.

2 of 6

2.78

1.22

0.0062

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:35990

Opioid Signalling, and Amine ligand-binding receptors

9 of 86

2.28

6.91

1.90e-16

CL:35991

Opioid Signalling, and Amine ligand-binding receptors

7 of 80

2.2

5.05

7.85e-12

CL:36005

Mixed, incl. Norepinephrine binding, and Mu-type opioid receptor binding

3 of 5

3.04

2.92

4.87e-06

CL:35999

G alpha (z) signalling events, and G-protein beta/gamma-subunit complex binding

4 of 35

2.32

2.81

3.40e-06

CL:36137

Dopamine receptors, and Response to gravity

3 of 7

2.89

2.79

7.83e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

lav04726

Serotonergic synapse

4 of 94

1.89

2.01

5.73e-05

lav04728

Dopaminergic synapse

4 of 101

1.86

1.98

5.73e-05

lav04713

Circadian entrainment

3 of 75

1.86

1.48

0.0010

lav05032

Morphine addiction

3 of 79

1.84

1.47

0.0010

lav04727

GABAergic synapse

3 of 77

1.85

1.47

0.0010

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-112311

Neurotransmitter clearance

3 of 9

2.78

2.53

2.30e-05

MAP-112315

Transmission across Chemical Synapses

6 of 261

1.62

2.12

3.93e-06

MAP-451326

Activation of kainate receptors upon glutamate binding

3 of 32

2.23

1.82

0.00034

MAP-4086398

Ca2+ pathway

3 of 41

2.12

1.68

0.00055

MAP-112316

Neuronal System

6 of 412

1.42

1.65

2.30e-05

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0003954

Dopaminergic system

3 of 4

3.14

2.87

6.19e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005834

Heterotrimeric G-protein complex

3 of 16

2.53

1.99

0.00020

GOCC:0071944

Cell periphery

9 of 4127

0.6

0.44

0.0051

GOCC:0005886

Plasma membrane

8 of 3874

0.58

0.36

0.0304

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0769

Symport

2 of 27

2.13

0.76

0.0383

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR016346

Guanine nucleotide-binding protein, beta subunit

2 of 4

2.96

0.86

0.0279

IPR001632

G-protein, beta subunit

2 of 6

2.78

0.86

0.0279

IPR000929

Dopamine receptor family

2 of 5

2.86

0.86

0.0279

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