PHISP_06970 protein (Phialosimplex sp. HF37)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

PHISP_06970

Uncharacterized protein. (250 aa)

Predicted Functional Partners:

PHISP_06427

0.763

PHISP_02526

0.754

PHISP_02421

0.754

PHISP_06872

0.749

PHISP_02830

0.749

PHISP_02745

0.749

PHISP_01424

0.749

PHISP_05104

0.687

PHISP_07989

0.660

PHISP_00598

0.642

Your Current Organism:

Phialosimplex sp. HF37

NCBI taxonomy Id: 1960876
Other names: P. sp. HF37

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PHISP_00598	PHISP_05104	A0A3M2TFJ1	A0A3M2T3V2	Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.	Vacuolar membrane protein.	0.561
PHISP_00598	PHISP_06427	A0A3M2TFJ1	A0A3M2SYS6	Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.	SH3 domain protein.	0.693
PHISP_00598	PHISP_06970	A0A3M2TFJ1	A0A3M2SXA7	Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.	Uncharacterized protein.	0.642
PHISP_01424	PHISP_05104	A0A3M2TD33	A0A3M2T3V2	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Vacuolar membrane protein.	0.727
PHISP_01424	PHISP_06427	A0A3M2TD33	A0A3M2SYS6	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	SH3 domain protein.	0.559
PHISP_01424	PHISP_06970	A0A3M2TD33	A0A3M2SXA7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Uncharacterized protein.	0.749
PHISP_02421	PHISP_05104	A0A3M2TAB8	A0A3M2T3V2	Uncharacterized protein.	Vacuolar membrane protein.	0.746
PHISP_02421	PHISP_06427	A0A3M2TAB8	A0A3M2SYS6	Uncharacterized protein.	SH3 domain protein.	0.855
PHISP_02421	PHISP_06970	A0A3M2TAB8	A0A3M2SXA7	Uncharacterized protein.	Uncharacterized protein.	0.754
PHISP_02526	PHISP_05104	A0A3M2T9Y0	A0A3M2T3V2	Uncharacterized protein.	Vacuolar membrane protein.	0.746
PHISP_02526	PHISP_06427	A0A3M2T9Y0	A0A3M2SYS6	Uncharacterized protein.	SH3 domain protein.	0.855
PHISP_02526	PHISP_06970	A0A3M2T9Y0	A0A3M2SXA7	Uncharacterized protein.	Uncharacterized protein.	0.754
PHISP_02745	PHISP_02830	A0A3M2T9A7	A0A3M2T942	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.659
PHISP_02745	PHISP_05104	A0A3M2T9A7	A0A3M2T3V2	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Vacuolar membrane protein.	0.727
PHISP_02745	PHISP_06427	A0A3M2T9A7	A0A3M2SYS6	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	SH3 domain protein.	0.559
PHISP_02745	PHISP_06970	A0A3M2T9A7	A0A3M2SXA7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Uncharacterized protein.	0.749
PHISP_02830	PHISP_02745	A0A3M2T942	A0A3M2T9A7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.659
PHISP_02830	PHISP_05104	A0A3M2T942	A0A3M2T3V2	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Vacuolar membrane protein.	0.727
PHISP_02830	PHISP_06427	A0A3M2T942	A0A3M2SYS6	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	SH3 domain protein.	0.570
PHISP_02830	PHISP_06872	A0A3M2T942	A0A3M2SXL4	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Calcium channel.	0.669

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Network Stats

number of nodes:

6

number of edges:

8

average node degree:

2.67

avg. local clustering coefficient:

0.828

expected number of edges:

5

PPI enrichment p-value:

0.146

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006729

Tetrahydrobiopterin biosynthetic process

2 of 2

2.77

1.17

0.0186

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008124

4-alpha-hydroxytetrahydrobiopterin dehydratase activity

2 of 2

2.77

1.34

0.0100

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2611

Mixed, incl. Diol biosynthetic process, and Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily

3 of 14

2.11

1.77

0.0014

CL:2629

Diol biosynthetic process, and Phosphoglycolate phosphatase-like, domain 2

2 of 5

2.38

1.24

0.0133

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

woc00350

Tyrosine metabolism

2 of 16

1.87

0.89

0.0390

woc00790

Folate biosynthesis

2 of 24

1.7

0.84

0.0412

woc00360

Phenylalanine metabolism

2 of 26

1.66

0.83

0.0412

woc01100

Metabolic pathways

5 of 667

0.65

0.39

0.0412

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01329

Pterin 4 alpha carbinolamine dehydratase

2 of 2

2.77

1.41

0.0081

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036428

Pterin 4 alpha carbinolamine dehydratase superfamily

2 of 2

2.77

1.13

0.0209

IPR001533

Pterin 4 alpha carbinolamine dehydratase

2 of 2

2.77

1.13

0.0209

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