PHISP_05756 protein (Phialosimplex sp. HF37)

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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Coexpression

Experiments

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[Homology]

Score

PHISP_05756

Uncharacterized protein. (337 aa)

Predicted Functional Partners:

PHISP_04041

0.773

PHISP_03035

0.767

PHISP_05559

0.766

PHISP_04527

0.758

PHISP_04050

0.741

PHISP_01332

0.721

PHISP_07147

0.699

PHISP_01349

0.686

PHISP_05195

0.681

PHISP_06742

0.678

Your Current Organism:

Phialosimplex sp. HF37

NCBI taxonomy Id: 1960876
Other names: P. sp. HF37

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PHISP_01332	PHISP_01349	A0A3M2TDI1	A0A3M2TDC7	Homoserine dehydrogenase.	Argininosuccinate synthase.	0.848
PHISP_01332	PHISP_04041	A0A3M2TDI1	A0A3M2T5L5	Homoserine dehydrogenase.	Aspartokinase.	0.996
PHISP_01332	PHISP_04050	A0A3M2TDI1	A0A3M2T5I2	Homoserine dehydrogenase.	Mitochondrial import protein MMP37.	0.890
PHISP_01332	PHISP_05756	A0A3M2TDI1	A0A3M2T0N2	Homoserine dehydrogenase.	Uncharacterized protein.	0.721
PHISP_01332	PHISP_06742	A0A3M2TDI1	A0A3M2SXW2	Homoserine dehydrogenase.	Fumarate hydratase.	0.715
PHISP_01349	PHISP_01332	A0A3M2TDC7	A0A3M2TDI1	Argininosuccinate synthase.	Homoserine dehydrogenase.	0.848
PHISP_01349	PHISP_04041	A0A3M2TDC7	A0A3M2T5L5	Argininosuccinate synthase.	Aspartokinase.	0.949
PHISP_01349	PHISP_04050	A0A3M2TDC7	A0A3M2T5I2	Argininosuccinate synthase.	Mitochondrial import protein MMP37.	0.631
PHISP_01349	PHISP_04527	A0A3M2TDC7	A0A3M2T495	Argininosuccinate synthase.	Calcineurin subunit B.	0.446
PHISP_01349	PHISP_05195	A0A3M2TDC7	A0A3M2T2B2	Argininosuccinate synthase.	Glutamine amidotransferases class-II.	0.746
PHISP_01349	PHISP_05559	A0A3M2TDC7	A0A3M2T1B5	Argininosuccinate synthase.	NADPH:adrenodoxin oxidoreductase, mitochondrial.	0.679
PHISP_01349	PHISP_05756	A0A3M2TDC7	A0A3M2T0N2	Argininosuccinate synthase.	Uncharacterized protein.	0.686
PHISP_01349	PHISP_06742	A0A3M2TDC7	A0A3M2SXW2	Argininosuccinate synthase.	Fumarate hydratase.	0.836
PHISP_01349	PHISP_07147	A0A3M2TDC7	A0A3M2SWU9	Argininosuccinate synthase.	Amidophosphoribosyltransferase.	0.841
PHISP_03035	PHISP_05195	A0A3M2T9M6	A0A3M2T2B2	Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatB/GatE family. GatB subfamily.	Glutamine amidotransferases class-II.	0.729
PHISP_03035	PHISP_05559	A0A3M2T9M6	A0A3M2T1B5	Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatB/GatE family. GatB subfamily.	NADPH:adrenodoxin oxidoreductase, mitochondrial.	0.778
PHISP_03035	PHISP_05756	A0A3M2T9M6	A0A3M2T0N2	Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatB/GatE family. GatB subfamily.	Uncharacterized protein.	0.767
PHISP_03035	PHISP_07147	A0A3M2T9M6	A0A3M2SWU9	Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatB/GatE family. GatB subfamily.	Amidophosphoribosyltransferase.	0.873
PHISP_04041	PHISP_01332	A0A3M2T5L5	A0A3M2TDI1	Aspartokinase.	Homoserine dehydrogenase.	0.996
PHISP_04041	PHISP_01349	A0A3M2T5L5	A0A3M2TDC7	Aspartokinase.	Argininosuccinate synthase.	0.949

page 1 of 4

Network Stats

number of nodes:

8

number of edges:

21

average node degree:

5.25

avg. local clustering coefficient:

0.925

expected number of edges:

7

PPI enrichment p-value:

1.98e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009082

Branched-chain amino acid biosynthetic process

8 of 14

2.22

5.61

2.59e-13

GO:0009098

Leucine biosynthetic process

5 of 8

2.25

3.67

3.28e-08

GO:0009097

Isoleucine biosynthetic process

4 of 7

2.22

2.84

2.13e-06

GO:1901607

Alpha-amino acid biosynthetic process

8 of 72

1.5

2.47

7.45e-09

GO:0009099

Valine biosynthetic process

3 of 4

2.33

2.19

6.74e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003861

3-isopropylmalate dehydratase activity

2 of 2

2.46

0.77

0.0403

GO:0016836

Hydro-lyase activity

3 of 29

1.47

0.67

0.0403

GO:0000287

Magnesium ion binding

4 of 64

1.25

0.62

0.0403

GO:0019842

Vitamin binding

3 of 39

1.34

0.62

0.0468

GO:0016829

Lyase activity

4 of 103

1.05

0.53

0.0468

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009316

3-isopropylmalate dehydratase complex

2 of 2

2.46

1.43

0.0023

GO:0005829

Cytosol

8 of 308

0.87

0.79

0.00016

GO:0005737

Cytoplasm

11 of 1058

0.48

0.4

0.00043

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1004

2-Oxocarboxylic acid metabolism, and Aspartate family amino acid biosynthetic process

9 of 43

1.78

4.01

1.51e-12

CL:1067

C5-Branched dibasic acid metabolism

5 of 8

2.25

3.69

2.97e-08

CL:1002

Cellular amino acid biosynthetic process, and Aminotransferase, class I/classII

10 of 86

1.52

3.05

1.51e-12

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

blep00290

Valine, leucine and isoleucine biosynthesis

10 of 13

2.34

8.38

4.80e-20

blep01210

2-Oxocarboxylic acid metabolism

8 of 26

1.95

4.69

6.24e-13

blep00770

Pantothenate and CoA biosynthesis

5 of 13

2.04

3.43

3.12e-08

blep00660

C5-Branched dibasic acid metabolism

4 of 10

2.06

2.83

1.18e-06

blep01230

Biosynthesis of amino acids

9 of 99

1.42

2.5

6.15e-11

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009316

3-isopropylmalate dehydratase complex

2 of 2

2.46

1.25

0.0050

GOCC:0005829

Cytosol

9 of 530

0.69

0.57

0.00067

GOCC:0005737

Cytoplasm

11 of 883

0.55

0.47

0.00026

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0100

Branched-chain amino acid biosynthesis

9 of 11

2.37

7.54

2.25e-17

KW-0432

Leucine biosynthesis

4 of 4

2.46

3.33

3.93e-07

KW-0456

Lyase

4 of 69

1.22

0.91

0.0041

KW-0460

Magnesium

4 of 102

1.05

0.69

0.0117

KW-0479

Metal-binding

6 of 276

0.8

0.57

0.0064

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