PHISP_05358 protein (Phialosimplex sp. HF37)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Score

PHISP_05358

D-lactate dehydrogenase. (604 aa)

Predicted Functional Partners:

PHISP_00074

0.949

PHISP_03112

0.930

PHISP_04113

0.902

PHISP_05481

0.900

PHISP_03974

0.899

PHISP_04715

0.898

PHISP_04619

0.892

PHISP_07534

0.891

PHISP_02087

0.889

PHISP_02531

0.888

Your Current Organism:

Phialosimplex sp. HF37

NCBI taxonomy Id: 1960876
Other names: P. sp. HF37

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PHISP_00074	PHISP_02087	A0A3M2TGQ3	A0A3M2TB43	Cytochrome b2; Belongs to the cytochrome b5 family.	D-lactate dehydrogenase.	0.957
PHISP_00074	PHISP_02531	A0A3M2TGQ3	A0A3M2TA67	Cytochrome b2; Belongs to the cytochrome b5 family.	D-lactate dehydrogenase.	0.932
PHISP_00074	PHISP_03112	A0A3M2TGQ3	A0A3M2T8F2	Cytochrome b2; Belongs to the cytochrome b5 family.	Cytochrome b2; Belongs to the cytochrome b5 family.	0.892
PHISP_00074	PHISP_04619	A0A3M2TGQ3	A0A3M2T3Y1	Cytochrome b2; Belongs to the cytochrome b5 family.	Acetolactate synthase.	0.890
PHISP_00074	PHISP_04715	A0A3M2TGQ3	A0A3M2T3K2	Cytochrome b2; Belongs to the cytochrome b5 family.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.904
PHISP_00074	PHISP_05358	A0A3M2TGQ3	A0A3M2T2F5	Cytochrome b2; Belongs to the cytochrome b5 family.	D-lactate dehydrogenase.	0.949
PHISP_00074	PHISP_05481	A0A3M2TGQ3	A0A3M2T2T4	Cytochrome b2; Belongs to the cytochrome b5 family.	Malic enzyme.	0.906
PHISP_00074	PHISP_07534	A0A3M2TGQ3	A0A3M2SVL9	Cytochrome b2; Belongs to the cytochrome b5 family.	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.885
PHISP_02087	PHISP_00074	A0A3M2TB43	A0A3M2TGQ3	D-lactate dehydrogenase.	Cytochrome b2; Belongs to the cytochrome b5 family.	0.957
PHISP_02087	PHISP_02531	A0A3M2TB43	A0A3M2TA67	D-lactate dehydrogenase.	D-lactate dehydrogenase.	0.890
PHISP_02087	PHISP_03112	A0A3M2TB43	A0A3M2T8F2	D-lactate dehydrogenase.	Cytochrome b2; Belongs to the cytochrome b5 family.	0.956
PHISP_02087	PHISP_03974	A0A3M2TB43	A0A3M2T5T4	D-lactate dehydrogenase.	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.899
PHISP_02087	PHISP_04113	A0A3M2TB43	A0A3M2T5K1	D-lactate dehydrogenase.	Pyruvate dehydrogenase e1 component.	0.902
PHISP_02087	PHISP_04619	A0A3M2TB43	A0A3M2T3Y1	D-lactate dehydrogenase.	Acetolactate synthase.	0.892
PHISP_02087	PHISP_04715	A0A3M2TB43	A0A3M2T3K2	D-lactate dehydrogenase.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.898
PHISP_02087	PHISP_05358	A0A3M2TB43	A0A3M2T2F5	D-lactate dehydrogenase.	D-lactate dehydrogenase.	0.889
PHISP_02087	PHISP_05481	A0A3M2TB43	A0A3M2T2T4	D-lactate dehydrogenase.	Malic enzyme.	0.900
PHISP_02087	PHISP_07534	A0A3M2TB43	A0A3M2SVL9	D-lactate dehydrogenase.	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.891
PHISP_02531	PHISP_00074	A0A3M2TA67	A0A3M2TGQ3	D-lactate dehydrogenase.	Cytochrome b2; Belongs to the cytochrome b5 family.	0.932
PHISP_02531	PHISP_02087	A0A3M2TA67	A0A3M2TB43	D-lactate dehydrogenase.	D-lactate dehydrogenase.	0.890

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

18

average node degree:

3.27

avg. local clustering coefficient:

0.895

expected number of edges:

21

PPI enrichment p-value:

0.759

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042843

D-xylose catabolic process

5 of 6

3.02

5.28

1.75e-10

GO:0042559

Pteridine-containing compound biosynthetic process

4 of 13

2.59

3.49

2.53e-07

GO:0006729

Tetrahydrobiopterin biosynthetic process

3 of 5

2.88

2.85

6.01e-06

GO:0044282

Small molecule catabolic process

6 of 215

1.54

2.06

2.33e-06

GO:0019568

Arabinose catabolic process

2 of 2

3.1

1.82

0.00052

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004032

alditol:NADP+ 1-oxidoreductase activity

5 of 7

2.95

5.32

1.35e-10

GO:0016616

Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

6 of 131

1.76

2.74

1.46e-07

GO:0016491

Oxidoreductase activity

9 of 913

1.09

1.33

3.18e-07

GO:0016646

Oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

2 of 13

2.29

1.05

0.0116

GO:0003824

Catalytic activity

11 of 3985

0.54

0.46

0.00026

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10292

Mixed, incl. Tetrahydrobiopterin metabolic process, and D-xylose catabolic process

7 of 15

2.77

7.39

5.11e-15

CL:10310

Tetrahydrobiopterin metabolic process, and Oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor

4 of 6

2.92

4.11

2.63e-08

CL:11394

Pyrimidine deoxyribonucleoside triphosphate metabolic process, and Dihydrofolate metabolic process

2 of 5

2.7

1.26

0.0052

CL:10294

Alditol catabolic process, and D-xylose catabolic process

2 of 5

2.7

1.26

0.0052

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00790

Folate biosynthesis

5 of 50

2.1

3.41

5.51e-08

map00670

One carbon pool by folate

2 of 16

2.2

1.26

0.0043

map00561

Glycerolipid metabolism

2 of 54

1.67

0.76

0.0317

map01100

Metabolic pathways

11 of 2462

0.75

4.36e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-196108

Pregnenolone biosynthesis

5 of 7

2.95

5.43

8.23e-11

MAP-193807

Synthesis of bile acids and bile salts via 27-hydroxycholesterol

5 of 7

2.95

5.43

8.23e-11

MAP-193144

Estrogen biosynthesis

5 of 8

2.89

5.4

8.23e-11

MAP-2162123

Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

5 of 11

2.76

5.25

1.13e-10

MAP-5652227

Fructose biosynthesis

5 of 13

2.68

5.1

1.78e-10

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00248

Aldo/keto reductase family

5 of 38

2.22

3.4

1.16e-07

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR018170

Aldo/keto reductase, conserved site

5 of 8

2.89

5.03

4.34e-10

IPR020471

Aldo-keto reductase

5 of 16

2.59

4.41

3.42e-09

IPR036812

NADP-dependent oxidoreductase domain superfamily

5 of 38

2.22

3.42

1.07e-07

IPR023210

NADP-dependent oxidoreductase domain

5 of 38

2.22

3.42

1.07e-07

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