PHISP_05006 protein (Phialosimplex sp. HF37)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

PHISP_05006

Uncharacterized protein. (110 aa)

Predicted Functional Partners:

PHISP_00343

0.996

PHISP_02137

0.995

PHISP_07130

0.994

PHISP_04429

0.994

PHISP_04985

0.992

PHISP_01697

0.992

PHISP_08677

0.981

PHISP_01704

0.977

PHISP_05836

0.975

PHISP_00508

0.975

Your Current Organism:

Phialosimplex sp. HF37

NCBI taxonomy Id: 1960876
Other names: P. sp. HF37

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PHISP_00343	PHISP_00508	A0A3M2TGI0	A0A3M2TFR4	Cytochrome C oxidase.	Cytochrome c1.	0.999
PHISP_00343	PHISP_01697	A0A3M2TGI0	A0A3M2TCB4	Cytochrome C oxidase.	Cytochrome C oxidase.	0.999
PHISP_00343	PHISP_01704	A0A3M2TGI0	A0A3M2TCC3	Cytochrome C oxidase.	Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	0.999
PHISP_00343	PHISP_02137	A0A3M2TGI0	A0A3M2TB35	Cytochrome C oxidase.	Uncharacterized protein.	0.998
PHISP_00343	PHISP_04429	A0A3M2TGI0	A0A3M2T5U7	Cytochrome C oxidase.	Uncharacterized protein.	0.999
PHISP_00343	PHISP_04985	A0A3M2TGI0	A0A3M2T2Y1	Cytochrome C oxidase.	Uncharacterized protein; Belongs to the cytochrome c oxidase subunit 6A family.	0.999
PHISP_00343	PHISP_05006	A0A3M2TGI0	A0A3M2T2U5	Cytochrome C oxidase.	Uncharacterized protein.	0.996
PHISP_00343	PHISP_05836	A0A3M2TGI0	A0A3M2T0K1	Cytochrome C oxidase.	Uncharacterized protein.	0.998
PHISP_00343	PHISP_07130	A0A3M2TGI0	A0A3M2SWT7	Cytochrome C oxidase.	Ubiquinol-cytochrome c reductase complex.	0.998
PHISP_00343	PHISP_08677	A0A3M2TGI0	A0A3M2SSA5	Cytochrome C oxidase.	COX2_CUA domain-containing protein.	0.997
PHISP_00508	PHISP_00343	A0A3M2TFR4	A0A3M2TGI0	Cytochrome c1.	Cytochrome C oxidase.	0.999
PHISP_00508	PHISP_01697	A0A3M2TFR4	A0A3M2TCB4	Cytochrome c1.	Cytochrome C oxidase.	0.999
PHISP_00508	PHISP_01704	A0A3M2TFR4	A0A3M2TCC3	Cytochrome c1.	Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	0.999
PHISP_00508	PHISP_02137	A0A3M2TFR4	A0A3M2TB35	Cytochrome c1.	Uncharacterized protein.	0.999
PHISP_00508	PHISP_04429	A0A3M2TFR4	A0A3M2T5U7	Cytochrome c1.	Uncharacterized protein.	0.999
PHISP_00508	PHISP_04985	A0A3M2TFR4	A0A3M2T2Y1	Cytochrome c1.	Uncharacterized protein; Belongs to the cytochrome c oxidase subunit 6A family.	0.995
PHISP_00508	PHISP_05006	A0A3M2TFR4	A0A3M2T2U5	Cytochrome c1.	Uncharacterized protein.	0.975
PHISP_00508	PHISP_05836	A0A3M2TFR4	A0A3M2T0K1	Cytochrome c1.	Uncharacterized protein.	0.999
PHISP_00508	PHISP_07130	A0A3M2TFR4	A0A3M2SWT7	Cytochrome c1.	Ubiquinol-cytochrome c reductase complex.	0.999
PHISP_00508	PHISP_08677	A0A3M2TFR4	A0A3M2SSA5	Cytochrome c1.	COX2_CUA domain-containing protein.	0.996

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

47

average node degree:

8.55

avg. local clustering coefficient:

0.968

expected number of edges:

19

PPI enrichment p-value:

5.62e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 103

1.4

2.42

8.13e-11

GO:0044271

Cellular nitrogen compound biosynthetic process

11 of 334

0.93

1.09

9.78e-09

GO:1901566

Organonitrogen compound biosynthetic process

11 of 441

0.81

0.85

1.55e-07

GO:0006414

Translational elongation

2 of 11

1.67

0.67

0.0487

GO:0044238

Primary metabolic process

11 of 1054

0.43

0.36

0.0012

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

7 of 55

1.51

2.2

3.03e-07

GO:0019843

rRNA binding

5 of 39

1.52

1.66

5.95e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

7 of 60

1.48

2.2

1.22e-07

GO:0044391

Ribosomal subunit

3 of 13

1.77

1.58

0.00045

GO:0015935

Small ribosomal subunit

2 of 6

1.93

1.16

0.0056

GO:0005622

Intracellular anatomical structure

11 of 976

0.46

0.4

0.00019

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:105

rRNA-binding

7 of 24

1.87

3.82

1.70e-10

CL:106

rRNA-binding

6 of 16

1.98

3.75

1.89e-09

CL:98

Ribosome

9 of 44

1.72

3.71

4.10e-12

CL:108

Ribosomal subunit, and K Homology domain, type 2

4 of 6

2.23

3.02

9.12e-07

CL:81

Translation, and Ribonucleoside triphosphate biosynthetic process

11 of 139

1.31

2.24

4.10e-12

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

tpz03010

Ribosome

7 of 52

1.54

2.44

3.38e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

5 of 42

1.49

1.55

0.00011

GOCC:0044391

Ribosomal subunit

3 of 16

1.68

1.25

0.0023

GOCC:0022627

Cytosolic small ribosomal subunit

2 of 6

1.93

1.03

0.0103

GOCC:0043229

Intracellular organelle

7 of 272

0.82

0.65

0.0016

GOCC:0005622

Intracellular

11 of 960

0.47

0.39

0.00089

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

7 of 53

1.53

2.35

7.98e-08

KW-0699

rRNA-binding

5 of 39

1.52

1.79

1.99e-05

KW-0251

Elongation factor

2 of 7

1.87

0.89

0.0188

KW-0648

Protein biosynthesis

3 of 41

1.27

0.74

0.0188

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