PHISP_04877 protein (Phialosimplex sp. HF37)

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

PHISP_04877

BZIP transcription factor HacA. (426 aa)

Predicted Functional Partners:

PHISP_05755

0.862

PHISP_00918

0.757

PHISP_05641

0.756

PHISP_00478

0.746

PHISP_03396

0.745

PHISP_06872

0.723

PHISP_02830

0.723

PHISP_02745

0.723

PHISP_01424

0.723

PHISP_04878

0.709

Your Current Organism:

Phialosimplex sp. HF37

NCBI taxonomy Id: 1960876
Other names: P. sp. HF37

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PHISP_00478	PHISP_01424	A0A3M2TFP2	A0A3M2TD33	Uncharacterized protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.624
PHISP_00478	PHISP_02745	A0A3M2TFP2	A0A3M2T9A7	Uncharacterized protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.624
PHISP_00478	PHISP_02830	A0A3M2TFP2	A0A3M2T942	Uncharacterized protein.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.624
PHISP_00478	PHISP_04877	A0A3M2TFP2	A0A3M2T358	Uncharacterized protein.	BZIP transcription factor HacA.	0.746
PHISP_00478	PHISP_05755	A0A3M2TFP2	A0A3M2T0M0	Uncharacterized protein.	Control protein.	0.541
PHISP_00478	PHISP_06872	A0A3M2TFP2	A0A3M2SXL4	Uncharacterized protein.	Calcium channel.	0.624
PHISP_00918	PHISP_03396	A0A3M2TEN8	A0A3M2T7L2	Kinetochore protein spc25.	Uncharacterized protein.	0.999
PHISP_00918	PHISP_04877	A0A3M2TEN8	A0A3M2T358	Kinetochore protein spc25.	BZIP transcription factor HacA.	0.757
PHISP_00918	PHISP_05641	A0A3M2TEN8	A0A3M2T0Y7	Kinetochore protein spc25.	Kinetochore protein NUF2.	0.999
PHISP_01424	PHISP_00478	A0A3M2TD33	A0A3M2TFP2	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Uncharacterized protein.	0.624
PHISP_01424	PHISP_04877	A0A3M2TD33	A0A3M2T358	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	BZIP transcription factor HacA.	0.723
PHISP_01424	PHISP_05755	A0A3M2TD33	A0A3M2T0M0	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Control protein.	0.750
PHISP_02745	PHISP_00478	A0A3M2T9A7	A0A3M2TFP2	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Uncharacterized protein.	0.624
PHISP_02745	PHISP_02830	A0A3M2T9A7	A0A3M2T942	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.659
PHISP_02745	PHISP_04877	A0A3M2T9A7	A0A3M2T358	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	BZIP transcription factor HacA.	0.723
PHISP_02745	PHISP_05755	A0A3M2T9A7	A0A3M2T0M0	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Control protein.	0.750
PHISP_02830	PHISP_00478	A0A3M2T942	A0A3M2TFP2	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Uncharacterized protein.	0.624
PHISP_02830	PHISP_02745	A0A3M2T942	A0A3M2T9A7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.659
PHISP_02830	PHISP_04877	A0A3M2T942	A0A3M2T358	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	BZIP transcription factor HacA.	0.723
PHISP_02830	PHISP_05755	A0A3M2T942	A0A3M2T0M0	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Control protein.	0.750

page 1 of 3

Network Stats

number of nodes:

5

number of edges:

5

average node degree:

2

avg. local clustering coefficient:

0.833

expected number of edges:

4

PPI enrichment p-value:

0.379

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0055085

Transmembrane transport

10 of 324

0.91

0.97

1.02e-06

GO:0006810

Transport

11 of 424

0.83

0.86

8.89e-07

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

11 of 575

0.7

0.67

2.88e-06

GO:0016021

Integral component of membrane

10 of 578

0.65

0.58

4.45e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3375

ABC transporters

11 of 81

1.55

3.39

1.29e-14

CL:3376

ABC transporters

10 of 75

1.54

3.16

6.99e-13

CL:3382

ABC transporters

7 of 37

1.69

3.02

3.55e-09

CL:3385

ABC transporters

6 of 25

1.8

3.01

3.07e-08

CL:3386

ABC transporters

5 of 19

1.84

2.68

5.91e-07

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

mas02010

ABC transporters

11 of 158

1.26

2.1

2.05e-12

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0055052

ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing

9 of 54

1.64

3.37

8.65e-12

GOCC:0016021

Integral component of membrane

10 of 150

1.24

1.94

8.15e-11

GOCC:0005886

Plasma membrane

10 of 356

0.87

0.93

2.45e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-1003

Cell membrane

10 of 218

1.08

1.39

1.56e-08

KW-0813

Transport

9 of 195

1.08

1.33

1.75e-07

KW-1133

Transmembrane helix

10 of 639

0.61

0.52

0.00018

KW-0812

Transmembrane

10 of 639

0.61

0.52

0.00018

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00528

Binding-protein-dependent transport system inner membrane component

9 of 119

1.3

1.91

1.12e-08

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000515

ABC transporter type 1, transmembrane domain MetI-like

10 of 122

1.33

2.15

3.53e-10

IPR035906

MetI-like superfamily

10 of 123

1.33

2.14

3.53e-10

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