STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PHISP_04015Genome instability protein. (255 aa)    
Predicted Functional Partners:
PHISP_03618
ERCC4 domain-containing protein.
    
 0.965
PHISP_06751
ERCC4 domain-containing protein.
    
 0.964
PHISP_03437
Uncharacterized protein.
    
 0.956
PHISP_06040
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.
    
 0.954
PHISP_05154
Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.
    
 0.954
PHISP_08625
TOP1Ac domain-containing protein.
    
 0.936
PHISP_07598
Uncharacterized protein.
    
 0.936
PHISP_01672
zf-GRF domain-containing protein.
    
 0.936
PHISP_08533
Uncharacterized protein.
    
 0.887
PHISP_08516
Uncharacterized protein.
    
 0.887
Your Current Organism:
Phialosimplex sp. HF37
NCBI taxonomy Id: 1960876
Other names: P. sp. HF37
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.