PHISP_00978 protein (Phialosimplex sp. HF37)

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

PHISP_00978

Uncharacterized protein. (166 aa)

Predicted Functional Partners:

PHISP_01607

0.999

PHISP_01908

0.958

PHISP_07139

0.952

PHISP_05061

0.922

PHISP_02978

0.900

PHISP_02391

0.895

PHISP_01474

0.842

PHISP_05206

0.795

PHISP_03866

0.786

PHISP_06593

0.785

Your Current Organism:

Phialosimplex sp. HF37

NCBI taxonomy Id: 1960876
Other names: P. sp. HF37

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PHISP_00978	PHISP_01474	A0A3M2TEA6	A0A3M2TE29	Uncharacterized protein.	Uncharacterized protein.	0.842
PHISP_00978	PHISP_01607	A0A3M2TEA6	A0A3M2TCN0	Uncharacterized protein.	Uncharacterized protein.	0.999
PHISP_00978	PHISP_01908	A0A3M2TEA6	A0A3M2TBY4	Uncharacterized protein.	Replication factor c.	0.958
PHISP_00978	PHISP_02391	A0A3M2TEA6	A0A3M2TAC8	Uncharacterized protein.	Replication factor C subunit.	0.895
PHISP_00978	PHISP_02978	A0A3M2TEA6	A0A3M2T8U0	Uncharacterized protein.	Replication factor C subunit.	0.900
PHISP_00978	PHISP_03866	A0A3M2TEA6	A0A3M2T629	Uncharacterized protein.	Helicase ATP-binding domain-containing protein.	0.786
PHISP_00978	PHISP_05061	A0A3M2TEA6	A0A3M2T2N7	Uncharacterized protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.922
PHISP_00978	PHISP_05206	A0A3M2TEA6	A0A3M2T292	Uncharacterized protein.	DNA polymerase.	0.795
PHISP_00978	PHISP_06593	A0A3M2TEA6	A0A3M2SYL1	Uncharacterized protein.	Uncharacterized protein.	0.785
PHISP_00978	PHISP_07139	A0A3M2TEA6	A0A3M2SXX7	Uncharacterized protein.	Replication factor C subunit.	0.952
PHISP_01474	PHISP_00978	A0A3M2TE29	A0A3M2TEA6	Uncharacterized protein.	Uncharacterized protein.	0.842
PHISP_01474	PHISP_01607	A0A3M2TE29	A0A3M2TCN0	Uncharacterized protein.	Uncharacterized protein.	0.879
PHISP_01474	PHISP_01908	A0A3M2TE29	A0A3M2TBY4	Uncharacterized protein.	Replication factor c.	0.999
PHISP_01474	PHISP_02391	A0A3M2TE29	A0A3M2TAC8	Uncharacterized protein.	Replication factor C subunit.	0.999
PHISP_01474	PHISP_02978	A0A3M2TE29	A0A3M2T8U0	Uncharacterized protein.	Replication factor C subunit.	0.999
PHISP_01474	PHISP_03866	A0A3M2TE29	A0A3M2T629	Uncharacterized protein.	Helicase ATP-binding domain-containing protein.	0.760
PHISP_01474	PHISP_05061	A0A3M2TE29	A0A3M2T2N7	Uncharacterized protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.852
PHISP_01474	PHISP_05206	A0A3M2TE29	A0A3M2T292	Uncharacterized protein.	DNA polymerase.	0.715
PHISP_01474	PHISP_06593	A0A3M2TE29	A0A3M2SYL1	Uncharacterized protein.	Uncharacterized protein.	0.679
PHISP_01474	PHISP_07139	A0A3M2TE29	A0A3M2SXX7	Uncharacterized protein.	Replication factor C subunit.	0.999

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

43

average node degree:

7.82

avg. local clustering coefficient:

0.849

expected number of edges:

19

PPI enrichment p-value:

1.35e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042559

Pteridine-containing compound biosynthetic process

3 of 10

2.8

2.82

6.50e-06

GO:0019752

Carboxylic acid metabolic process

8 of 422

1.6

2.74

5.49e-09

GO:0032787

Monocarboxylic acid metabolic process

5 of 159

1.82

2.45

2.43e-06

GO:0009072

Aromatic amino acid family metabolic process

3 of 26

2.38

2.24

5.72e-05

GO:0044281

Small molecule metabolic process

9 of 765

1.39

2.2

5.49e-09

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016646

Oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor

3 of 13

2.68

2.55

1.93e-05

GO:0016747

Acyltransferase activity, transferring groups other than amino-acyl groups

5 of 138

1.88

2.41

4.92e-06

GO:0070404

NADH binding

2 of 2

3.32

1.99

0.00026

GO:0070402

NADPH binding

2 of 2

3.32

1.99

0.00026

GO:0004155

6,7-dihydropteridine reductase activity

2 of 2

3.32

1.99

0.00026

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0110165

Cellular anatomical entity

11 of 9316

0.39

0.28

0.0300

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11741

Mixed, incl. Fatty acyl-CoA biosynthesis, and Short-chain dehydrogenase/reductase SDR

9 of 190

2.0

5.25

2.32e-14

CL:11786

ChREBP activates metabolic gene expression, and Fatty acid synthase activity

5 of 23

2.66

4.76

8.02e-10

CL:12104

Phenylalanine metabolism, and eNOS activation

4 of 7

3.08

4.61

3.56e-09

CL:11788

Fatty acid biosynthesis, and Polyketide synthase, ketoreductase domain

4 of 13

2.81

4.22

1.37e-08

CL:11804

Fatty acid biosynthesis

2 of 5

2.92

1.86

0.00042

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00790

Folate biosynthesis

5 of 39

2.43

4.5

1.16e-09

map00061

Fatty acid biosynthesis

2 of 12

2.54

1.67

0.00085

map01100

Metabolic pathways

11 of 2264

1.01

1.29

1.16e-09

map01212

Fatty acid metabolism

2 of 45

1.97

1.1

0.0075

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-196854

Metabolism of vitamins and cofactors

5 of 148

1.85

2.5

2.29e-06

MAP-163765

ChREBP activates metabolic gene expression

3 of 31

2.31

2.14

8.13e-05

MAP-196849

Metabolism of water-soluble vitamins and cofactors

4 of 105

1.9

2.07

4.30e-05

MAP-8978868

Fatty acid metabolism

4 of 107

1.89

2.06

4.30e-05

MAP-199220

Vitamin B5 (pantothenate) metabolism

3 of 38

2.22

2.03

0.00012

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005737

Cytoplasm

9 of 2924

0.81

0.71

0.00029

GOCC:0005622

Intracellular

10 of 6691

0.5

0.36

0.0090

GOCC:0110165

Cellular anatomical entity

11 of 8287

0.44

0.35

0.0051

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0596

Phosphopantetheine

3 of 33

2.28

2.03

0.00013

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00106

Short chain dehydrogenase

3 of 10

2.8

2.45

3.18e-05

PF13469

Sulfotransferase family

2 of 9

2.67

1.16

0.0078

PF02801

Beta-ketoacyl synthase, C-terminal domain

2 of 16

2.42

1.0

0.0145

PF00109

Beta-ketoacyl synthase, N-terminal domain

2 of 16

2.42

1.0

0.0145

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036291

NAD(P)-binding domain superfamily

6 of 239

1.72

2.34

2.18e-06

IPR013968

Polyketide synthase, ketoreductase domain

3 of 22

2.46

1.86

0.00034

IPR020806

Polyketide synthase, phosphopantetheine-binding domain

3 of 29

2.34

1.76

0.00048

IPR009081

Phosphopantetheine binding ACP domain

3 of 34

2.27

1.72

0.00056

IPR036736

ACP-like superfamily

3 of 35

2.25

1.71

0.00056

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00823

Phosphopantetheine attachment site

2 of 17

2.39

1.04

0.0123

SM00822

This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group.

2 of 18

2.37

1.04

0.0123

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