PHISP_01001 protein (Phialosimplex sp. HF37)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

PHISP_01001

Developmental regulator VosA. (151 aa)

Predicted Functional Partners:

PHISP_01002

0.899

PHISP_05794

0.665

PHISP_01969

0.633

NOP7

0.624

PHISP_05825

0.589

ERB1

0.582

PHISP_03595

0.546

YTM1

0.543

PHISP_05027

0.504

PHISP_06157

0.497

Your Current Organism:

Phialosimplex sp. HF37

NCBI taxonomy Id: 1960876
Other names: P. sp. HF37

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ERB1	NOP7	A0A3M2TFC9	A0A3M2TCS7	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.999
ERB1	PHISP_01001	A0A3M2TFC9	A0A3M2TEI4	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Developmental regulator VosA.	0.582
ERB1	PHISP_01002	A0A3M2TFC9	A0A3M2TEB8	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Developmental regulator VosA.	0.582
ERB1	PHISP_01969	A0A3M2TFC9	A0A3M2TBG3	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Ipi1_N domain-containing protein.	0.809
ERB1	PHISP_03595	A0A3M2TFC9	A0A3M2T6U6	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Ulp1 protease family protein.	0.744
ERB1	PHISP_05794	A0A3M2TFC9	A0A3M2T0H9	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	WD_REPEATS_REGION domain-containing protein.	0.975
ERB1	PHISP_05825	A0A3M2TFC9	A0A3M2T1V8	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	CLP1_P domain-containing protein.	0.815
ERB1	PHISP_06157	A0A3M2TFC9	A0A3M2SZJ9	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	GTP-binding protein.	0.998
ERB1	YTM1	A0A3M2TFC9	A0A3M2SV96	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Ribosome biogenesis protein YTM1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.999
NOP7	ERB1	A0A3M2TCS7	A0A3M2TFC9	Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.999
NOP7	PHISP_01001	A0A3M2TCS7	A0A3M2TEI4	Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Developmental regulator VosA.	0.624
NOP7	PHISP_01002	A0A3M2TCS7	A0A3M2TEB8	Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Developmental regulator VosA.	0.624
NOP7	PHISP_01969	A0A3M2TCS7	A0A3M2TBG3	Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Ipi1_N domain-containing protein.	0.834
NOP7	PHISP_03595	A0A3M2TCS7	A0A3M2T6U6	Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Ulp1 protease family protein.	0.710
NOP7	PHISP_05794	A0A3M2TCS7	A0A3M2T0H9	Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	WD_REPEATS_REGION domain-containing protein.	0.954
NOP7	PHISP_05825	A0A3M2TCS7	A0A3M2T1V8	Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	CLP1_P domain-containing protein.	0.688
NOP7	PHISP_06157	A0A3M2TCS7	A0A3M2SZJ9	Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	GTP-binding protein.	0.999
NOP7	YTM1	A0A3M2TCS7	A0A3M2SV96	Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	Ribosome biogenesis protein YTM1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.999
PHISP_01001	ERB1	A0A3M2TEI4	A0A3M2TFC9	Developmental regulator VosA.	Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.582
PHISP_01001	NOP7	A0A3M2TEI4	A0A3M2TCS7	Developmental regulator VosA.	Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.624

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Network Stats

number of nodes:

11

number of edges:

47

average node degree:

8.55

avg. local clustering coefficient:

0.968

expected number of edges:

23

PPI enrichment p-value:

5.25e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051607

Defense response to virus

6 of 8

2.29

4.25

1.91e-09

GO:0006278

RNA-templated DNA biosynthetic process

3 of 3

2.42

2.2

7.08e-05

GO:0043571

Maintenance of CRISPR repeat elements

2 of 2

2.42

1.24

0.0052

GO:0006259

DNA metabolic process

7 of 159

1.06

1.08

4.63e-05

GO:0090304

Nucleic acid metabolic process

8 of 313

0.83

0.73

0.00021

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003964

RNA-directed DNA polymerase activity

5 of 5

2.42

3.77

4.11e-08

GO:0140097

Catalytic activity, acting on DNA

6 of 103

1.18

1.19

0.00012

GO:0140640

Catalytic activity, acting on a nucleic acid

8 of 198

1.02

1.08

1.59e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5482

Response to virus, and RNA-directed DNA polymerase activity

11 of 15

2.28

8.56

1.74e-21

CL:5485

Response to virus

7 of 10

2.26

5.33

3.12e-12

CL:5487

Response to virus

3 of 5

2.2

1.83

0.00030

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00540

Lipopolysaccharide biosynthesis

5 of 14

1.97

2.93

3.67e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0695

RNA-directed DNA polymerase

2 of 2

2.42

0.98

0.0159

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08388

Group II intron, maturase-specific domain

2 of 2

2.42

0.79

0.0363

PF00078

Reverse transcriptase (RNA-dependent DNA polymerase)

2 of 2

2.42

0.79

0.0363

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