PHISP_00646 protein (Phialosimplex sp. HF37)

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

Node Content

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

PHISP_00646

Mitochondrial carrier protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (333 aa)

Predicted Functional Partners:

PHISP_00642

0.899

PHISP_03160

0.885

PHISP_03818

0.624

PHISP_01844

0.460

PHISP_03730

0.440

PHISP_06028

0.405

PHISP_06334

0.400

Your Current Organism:

Phialosimplex sp. HF37

NCBI taxonomy Id: 1960876
Other names: P. sp. HF37

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PHISP_00642	PHISP_00646	A0A3M2TFH6	A0A3M2TFF3	HAL protein kinase.	Mitochondrial carrier protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.899
PHISP_00642	PHISP_03160	A0A3M2TFH6	A0A3M2T9A3	HAL protein kinase.	WD repeat protein.	0.898
PHISP_00646	PHISP_00642	A0A3M2TFF3	A0A3M2TFH6	Mitochondrial carrier protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	HAL protein kinase.	0.899
PHISP_00646	PHISP_01844	A0A3M2TFF3	A0A3M2TC47	Mitochondrial carrier protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix; Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.	0.460
PHISP_00646	PHISP_03160	A0A3M2TFF3	A0A3M2T9A3	Mitochondrial carrier protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	WD repeat protein.	0.885
PHISP_00646	PHISP_03730	A0A3M2TFF3	A0A3M2T6Q1	Mitochondrial carrier protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	Uncharacterized protein.	0.440
PHISP_00646	PHISP_03818	A0A3M2TFF3	A0A3M2T6K5	Mitochondrial carrier protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	Cysteine desulfurase.	0.624
PHISP_00646	PHISP_06028	A0A3M2TFF3	A0A3M2SZW1	Mitochondrial carrier protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	Uncharacterized protein.	0.405
PHISP_00646	PHISP_06334	A0A3M2TFF3	A0A3M2SZ53	Mitochondrial carrier protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	Proteasome regulatory.	0.400
PHISP_01844	PHISP_00646	A0A3M2TC47	A0A3M2TFF3	Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix; Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.	Mitochondrial carrier protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.460
PHISP_03160	PHISP_00642	A0A3M2T9A3	A0A3M2TFH6	WD repeat protein.	HAL protein kinase.	0.898
PHISP_03160	PHISP_00646	A0A3M2T9A3	A0A3M2TFF3	WD repeat protein.	Mitochondrial carrier protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.885
PHISP_03730	PHISP_00646	A0A3M2T6Q1	A0A3M2TFF3	Uncharacterized protein.	Mitochondrial carrier protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.440
PHISP_03818	PHISP_00646	A0A3M2T6K5	A0A3M2TFF3	Cysteine desulfurase.	Mitochondrial carrier protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.624
PHISP_06028	PHISP_00646	A0A3M2SZW1	A0A3M2TFF3	Uncharacterized protein.	Mitochondrial carrier protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.405
PHISP_06028	PHISP_06334	A0A3M2SZW1	A0A3M2SZ53	Uncharacterized protein.	Proteasome regulatory.	0.444
PHISP_06334	PHISP_00646	A0A3M2SZ53	A0A3M2TFF3	Proteasome regulatory.	Mitochondrial carrier protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.400
PHISP_06334	PHISP_06028	A0A3M2SZ53	A0A3M2SZW1	Proteasome regulatory.	Uncharacterized protein.	0.444

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

14

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 103

1.39

2.4

8.86e-11

GO:0044238

Primary metabolic process

11 of 1033

0.43

0.36

0.0011

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

9 of 53

1.63

3.29

2.17e-11

GO:0070180

Large ribosomal subunit rRNA binding

2 of 2

2.4

1.09

0.0098

GO:0019843

rRNA binding

4 of 40

1.4

1.07

0.0029

GO:0003723

RNA binding

5 of 89

1.15

0.89

0.0029

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

9 of 56

1.61

3.29

6.22e-12

GO:0044391

Ribosomal subunit

5 of 14

1.96

3.18

6.49e-08

GO:0015934

Large ribosomal subunit

3 of 8

1.98

1.97

9.75e-05

GO:0015935

Small ribosomal subunit

2 of 6

1.93

1.24

0.0038

GO:0005622

Intracellular anatomical structure

11 of 972

0.46

0.4

0.00011

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:103

Ribosomal protein

10 of 65

1.59

3.36

7.11e-13

CL:107

Ribosomal protein

9 of 58

1.6

3.22

8.40e-12

CL:110

Ribosomal protein

8 of 51

1.6

3.01

2.01e-10

CL:112

Ribosomal protein

7 of 45

1.6

2.71

7.76e-09

CL:155

Structural constituent of ribosome

4 of 16

1.8

2.07

2.61e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

9 of 55

1.62

3.32

6.37e-12

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

7 of 40

1.65

2.76

1.68e-08

GOCC:0044391

Ribosomal subunit

4 of 16

1.8

2.09

2.30e-05

GOCC:0015935

Small ribosomal subunit

3 of 9

1.93

1.74

0.00028

GOCC:0043229

Intracellular organelle

10 of 270

0.97

1.14

9.78e-08

GOCC:0022627

Cytosolic small ribosomal subunit

2 of 7

1.86

1.0

0.0114

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

9 of 54

1.63

3.33

8.02e-12

KW-0699

rRNA-binding

4 of 38

1.43

1.25

0.00083

KW-0810

Translation regulation

2 of 5

2.01

1.03

0.0108

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