PHISP_00536 protein (Phialosimplex sp. HF37)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

PHISP_00536

Uncharacterized protein. (340 aa)

Predicted Functional Partners:

PHISP_08268

0.691

PHISP_07560

0.671

PHISP_03890

0.629

PHISP_05034

0.617

PHISP_00218

0.617

PHISP_00639

0.617

PHISP_08201

0.606

PHISP_08016

0.606

PHISP_07853

0.606

PHISP_07772

0.606

Your Current Organism:

Phialosimplex sp. HF37

NCBI taxonomy Id: 1960876
Other names: P. sp. HF37

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PHISP_00218	PHISP_00536	A0A3M2TGC9	A0A3M2TFV9	Ribosomal protein.	Uncharacterized protein.	0.617
PHISP_00218	PHISP_00639	A0A3M2TGC9	A0A3M2TGS0	Ribosomal protein.	Uncharacterized protein.	0.944
PHISP_00218	PHISP_03890	A0A3M2TGC9	A0A3M2T767	Ribosomal protein.	Uncharacterized protein.	0.988
PHISP_00218	PHISP_05034	A0A3M2TGC9	A0A3M2T2S1	Ribosomal protein.	Uncharacterized protein.	0.986
PHISP_00218	PHISP_07560	A0A3M2TGC9	A0A3M2SWH6	Ribosomal protein.	Eukaryotic mitochondrial regulator protein.	0.931
PHISP_00218	PHISP_07772	A0A3M2TGC9	A0A3M2SUV3	Ribosomal protein.	Ribosomal_L2_C domain-containing protein.	0.990
PHISP_00218	PHISP_07853	A0A3M2TGC9	A0A3M2SUQ9	Ribosomal protein.	Superoxide dismutase.	0.945
PHISP_00218	PHISP_08016	A0A3M2TGC9	A0A3M2SUJ5	Ribosomal protein.	Ribosomal protein.	0.927
PHISP_00218	PHISP_08201	A0A3M2TGC9	A0A3M2STQ1	Ribosomal protein.	60S ribosomal protein L25.	0.926
PHISP_00218	PHISP_08268	A0A3M2TGC9	A0A3M2STH2	Ribosomal protein.	KOW motif domain protein.	0.606
PHISP_00536	PHISP_00218	A0A3M2TFV9	A0A3M2TGC9	Uncharacterized protein.	Ribosomal protein.	0.617
PHISP_00536	PHISP_00639	A0A3M2TFV9	A0A3M2TGS0	Uncharacterized protein.	Uncharacterized protein.	0.617
PHISP_00536	PHISP_03890	A0A3M2TFV9	A0A3M2T767	Uncharacterized protein.	Uncharacterized protein.	0.629
PHISP_00536	PHISP_05034	A0A3M2TFV9	A0A3M2T2S1	Uncharacterized protein.	Uncharacterized protein.	0.617
PHISP_00536	PHISP_07560	A0A3M2TFV9	A0A3M2SWH6	Uncharacterized protein.	Eukaryotic mitochondrial regulator protein.	0.671
PHISP_00536	PHISP_07772	A0A3M2TFV9	A0A3M2SUV3	Uncharacterized protein.	Ribosomal_L2_C domain-containing protein.	0.606
PHISP_00536	PHISP_07853	A0A3M2TFV9	A0A3M2SUQ9	Uncharacterized protein.	Superoxide dismutase.	0.606
PHISP_00536	PHISP_08016	A0A3M2TFV9	A0A3M2SUJ5	Uncharacterized protein.	Ribosomal protein.	0.606
PHISP_00536	PHISP_08201	A0A3M2TFV9	A0A3M2STQ1	Uncharacterized protein.	60S ribosomal protein L25.	0.606
PHISP_00536	PHISP_08268	A0A3M2TFV9	A0A3M2STH2	Uncharacterized protein.	KOW motif domain protein.	0.691

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.868

expected number of edges:

11

PPI enrichment p-value:

0.000207

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009231

Riboflavin biosynthetic process

6 of 8

2.48

4.92

1.72e-10

GO:0018130

Heterocycle biosynthetic process

8 of 253

1.1

1.27

2.73e-06

GO:1901362

Organic cyclic compound biosynthetic process

8 of 268

1.08

1.21

3.82e-06

GO:0009156

Ribonucleoside monophosphate biosynthetic process

3 of 38

1.5

0.98

0.0071

GO:0044271

Cellular nitrogen compound biosynthetic process

8 of 353

0.96

2.89e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003935

GTP cyclohydrolase II activity

2 of 2

2.6

1.06

0.0117

GO:0016814

Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

3 of 17

1.85

1.04

0.0092

GO:0016765

Transferase activity, transferring alkyl or aryl (other than methyl) groups

3 of 24

1.7

0.96

0.0117

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005829

Cytosol

6 of 414

0.76

0.46

0.0271

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:998

Riboflavin biosynthesis

5 of 5

2.6

4.29

6.15e-09

CL:996

Mixed, incl. Pantothenate metabolic process, and Riboflavin metabolism

6 of 18

2.12

3.81

6.15e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

psul00740

Riboflavin metabolism

6 of 7

2.53

5.57

9.08e-12

psul01110

Biosynthesis of secondary metabolites

8 of 380

0.92

2.57e-05

psul00790

Folate biosynthesis

2 of 21

1.58

0.71

0.0363

psul02024

Quorum sensing

3 of 88

1.13

0.6

0.0363

psul01100

Metabolic pathways

9 of 842

0.63

0.52

0.00053

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0686

Riboflavin biosynthesis

4 of 4

2.6

3.46

3.00e-07

KW-0630

Potassium

2 of 5

2.2

1.03

0.0121

KW-0862

Zinc

3 of 80

1.18

0.57

0.0488

KW-0479

Metal-binding

5 of 272

0.87

0.53

0.0219

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00925

GTP cyclohydrolase II

2 of 2

2.6

0.92

0.0210

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