STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PHISP_00043Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)    
Predicted Functional Partners:
PHISP_05708
Histone H2B; Belongs to the histone H2B family.
 
 0.998
PHISP_00791
Uncharacterized protein.
    
  0.998
PHISP_05709
Histone H2A; Belongs to the histone H2A family.
 
 0.994
PHISP_04650
Histone H3; Belongs to the histone H3 family.
 
 
 0.990
PHISP_04247
Histone H2A; Belongs to the histone H2A family.
 
 
 0.977
PHISP_04318
Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family.
    
 0.973
PHISP_06772
WD_REPEATS_REGION domain-containing protein.
    
 0.971
PHISP_07592
Histone H3.
 
 
 0.969
PHISP_03226
Component swd1.
    
 0.951
PHISP_06581
Uncharacterized protein.
    
 0.945
Your Current Organism:
Phialosimplex sp. HF37
NCBI taxonomy Id: 1960876
Other names: P. sp. HF37
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.