STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAC1Nuclear distribution protein PAC1; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs; Belongs to the WD repeat LIS1/nudF family. (468 aa)    
Predicted Functional Partners:
A0A136J5J5
Dynein heavy chain, N-terminal region 1-domain-containing protein.
    
 0.972
A0A136JG56
HSP20-like chaperone.
    
 0.892
A0A136J4G5
Cytoplasmic dynein-like protein 1 intermediate chain 2.
   
 0.882
A0A136IVA3
NACHT domain-containing protein.
 
   
  0.865
A0A136JFW5
Dynamitin-domain-containing protein.
    
 0.860
A0A136IXE8
Dynactin.
    
 0.850
A0A136J1Y6
Dynein light chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
    
 0.839
A0A136JAF4
Dynein light intermediate chain-domain-containing protein.
   
 0.804
A0A136J901
Uncharacterized protein.
    
 0.794
A0A136JF00
Uncharacterized protein.
    
 0.792
Your Current Organism:
Microdochium bolleyi
NCBI taxonomy Id: 196109
Other names: M. bolleyi
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.