A0A136J8Z0 protein (Microdochium bolleyi) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

A0A136J8Z0

Alkyl hydroperoxide reductase-like protein/ thiol specific antioxidant/ mal allergen. (215 aa)

Predicted Functional Partners:

A0A136JKI3

0.861

A0A136IQ22

0.832

A0A136IN47

0.760

A0A136J2P2

0.730

A0A136ITF0

0.585

A0A136J287

0.585

A0A136JHY0

0.547

A0A136IJG0

0.529

A0A136IJW3

0.529

A0A136ITB9

0.529

Your Current Organism:

Microdochium bolleyi

NCBI taxonomy Id: 196109
Other names: M. bolleyi

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A136IJG0	A0A136IQ22	Arabinan endo-1,5-alpha-L-arabinosidase A.	Tryptophan synthase.	0.482
A0A136IJG0	A0A136J8Z0	Arabinan endo-1,5-alpha-L-arabinosidase A.	Alkyl hydroperoxide reductase-like protein/ thiol specific antioxidant/ mal allergen.	0.529
A0A136IJG0	A0A136JKI3	Arabinan endo-1,5-alpha-L-arabinosidase A.	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	0.552
A0A136IJW3	A0A136IQ22	Arabinan endo-1,5-alpha-L-arabinosidase; Belongs to the glycosyl hydrolase 43 family.	Tryptophan synthase.	0.482
A0A136IJW3	A0A136J8Z0	Arabinan endo-1,5-alpha-L-arabinosidase; Belongs to the glycosyl hydrolase 43 family.	Alkyl hydroperoxide reductase-like protein/ thiol specific antioxidant/ mal allergen.	0.529
A0A136IJW3	A0A136JKI3	Arabinan endo-1,5-alpha-L-arabinosidase; Belongs to the glycosyl hydrolase 43 family.	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	0.552
A0A136IN47	A0A136IQ22	Homoserine dehydrogenase.	Tryptophan synthase.	0.942
A0A136IN47	A0A136ITF0	Homoserine dehydrogenase.	Uncharacterized protein.	0.764
A0A136IN47	A0A136J287	Homoserine dehydrogenase.	Rhodanese-like domain-containing protein.	0.764
A0A136IN47	A0A136J2P2	Homoserine dehydrogenase.	Homocysteine S-methyltransferase.	0.916
A0A136IN47	A0A136J8Z0	Homoserine dehydrogenase.	Alkyl hydroperoxide reductase-like protein/ thiol specific antioxidant/ mal allergen.	0.760
A0A136IN47	A0A136JKI3	Homoserine dehydrogenase.	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	0.891
A0A136IQ22	A0A136IJG0	Tryptophan synthase.	Arabinan endo-1,5-alpha-L-arabinosidase A.	0.482
A0A136IQ22	A0A136IJW3	Tryptophan synthase.	Arabinan endo-1,5-alpha-L-arabinosidase; Belongs to the glycosyl hydrolase 43 family.	0.482
A0A136IQ22	A0A136IN47	Tryptophan synthase.	Homoserine dehydrogenase.	0.942
A0A136IQ22	A0A136ITB9	Tryptophan synthase.	Glycosyl hydrolase.	0.482
A0A136IQ22	A0A136ITF0	Tryptophan synthase.	Uncharacterized protein.	0.452
A0A136IQ22	A0A136J287	Tryptophan synthase.	Rhodanese-like domain-containing protein.	0.452
A0A136IQ22	A0A136J2P2	Tryptophan synthase.	Homocysteine S-methyltransferase.	0.606
A0A136IQ22	A0A136J8Z0	Tryptophan synthase.	Alkyl hydroperoxide reductase-like protein/ thiol specific antioxidant/ mal allergen.	0.832

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

22

average node degree:

4

avg. local clustering coefficient:

0.933

expected number of edges:

17

PPI enrichment p-value:

0.157

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022900

Electron transport chain

8 of 58

1.98

4.42

1.20e-11

GO:0006120

Mitochondrial electron transport, NADH to ubiquinone

4 of 8

2.53

3.21

8.10e-07

GO:0019646

Aerobic electron transport chain

5 of 30

2.06

2.89

8.10e-07

GO:0042775

Mitochondrial ATP synthesis coupled electron transport

5 of 31

2.04

2.88

8.10e-07

GO:0032981

Mitochondrial respiratory chain complex I assembly

3 of 16

2.11

1.65

0.00062

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008137

NADH dehydrogenase (ubiquinone) activity

7 of 20

2.38

5.8

7.60e-13

GO:0015453

Oxidoreduction-driven active transmembrane transporter activity

8 of 35

2.19

5.66

1.31e-13

GO:0009055

Electron transfer activity

8 of 56

1.99

4.8

7.95e-13

GO:0051539

4 iron, 4 sulfur cluster binding

3 of 38

1.73

1.25

0.0025

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005747

Mitochondrial respiratory chain complex I

9 of 19

2.51

8.72

2.85e-19

GO:1902495

Transmembrane transporter complex

10 of 33

2.32

8.15

1.05e-19

GO:0005746

Mitochondrial respirasome

10 of 39

2.24

7.75

1.79e-19

GO:0098803

Respiratory chain complex

10 of 40

2.23

7.7

1.79e-19

GO:1990204

Oxidoreductase complex

10 of 54

2.1

6.86

9.19e-19

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6225

NADH dehydrogenase complex

9 of 15

2.61

9.05

2.43e-19

CL:6213

NADH dehydrogenase complex, and NADH dehydrogenase (quinone) activity

10 of 34

2.3

7.97

2.43e-19

CL:6227

NADH dehydrogenase complex

6 of 8

2.71

6.47

3.04e-13

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

10 of 114

1.78

4.57

1.64e-15

map01100

Metabolic pathways

11 of 1992

0.58

0.51

3.43e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6799198

Complex I biogenesis

9 of 31

2.3

7.24

3.15e-17

MAP-611105

Respiratory electron transport

10 of 61

2.05

6.23

2.82e-17

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

10 of 72

1.98

5.84

4.35e-17

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

10 of 134

1.71

4.11

1.16e-14

MAP-1430728

Metabolism

10 of 1389

0.69

0.61

7.85e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070469

Respirasome

6 of 51

1.91

3.11

6.05e-08

GOCC:0005743

Mitochondrial inner membrane

6 of 154

1.43

1.73

9.59e-06

GOCC:0005746

Mitochondrial respirasome

3 of 22

1.97

1.65

0.00049

GOCC:0031966

Mitochondrial membrane

7 of 234

1.31

1.61

4.37e-06

GOCC:0098803

Respiratory chain complex

3 of 25

1.91

1.58

0.00064

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0830

Ubiquinone

7 of 33

2.16

5.02

5.25e-12

KW-0679

Respiratory chain

2 of 4

2.53

1.35

0.0034

KW-1278

Translocase

2 of 18

1.88

0.92

0.0172

KW-0813

Transport

4 of 202

1.13

0.75

0.0100

KW-0999

Mitochondrion inner membrane

2 of 33

1.62

0.68

0.0445

(more ...)

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