OQY66026.1 protein (Polyangiaceae bacterium UTPRO1)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Gene Fusion

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Score

OQY66026.1

Hypothetical protein. (210 aa)

Predicted Functional Partners:

OQY64893.1

0.989

OQY66678.1

0.988

OQY67576.1

0.985

OQY68459.1

0.977

OQY67953.1

0.977

OQY68019.1

0.971

OQY69097.1

0.948

OQY68820.1

0.937

OQY69142.1

0.930

OQY67943.1

0.930

Your Current Organism:

Polyangiaceae bacterium UTPRO1

NCBI taxonomy Id: 1961108
Other names: P. bacterium UTPRO1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OQY64893.1	OQY66026.1	B6D46_15660	B6D46_12400	Hypothetical protein.	Hypothetical protein.	0.989
OQY64893.1	OQY66678.1	B6D46_15660	B6D46_09460	Hypothetical protein.	Hypothetical protein.	0.998
OQY64893.1	OQY67576.1	B6D46_15660	B6D46_06000	Hypothetical protein.	Hypothetical protein.	0.999
OQY64893.1	OQY67943.1	B6D46_15660	B6D46_05170	Hypothetical protein.	Hypothetical protein.	0.991
OQY64893.1	OQY67953.1	B6D46_15660	B6D46_05220	Hypothetical protein.	Hypothetical protein.	0.997
OQY64893.1	OQY68019.1	B6D46_15660	B6D46_04915	Hypothetical protein.	Hypothetical protein.	0.997
OQY64893.1	OQY68459.1	B6D46_15660	B6D46_03430	Hypothetical protein.	Hypothetical protein.	0.996
OQY64893.1	OQY68820.1	B6D46_15660	B6D46_01615	Hypothetical protein.	Hypothetical protein.	0.998
OQY64893.1	OQY69097.1	B6D46_15660	B6D46_01005	Hypothetical protein.	Hypothetical protein.	0.997
OQY64893.1	OQY69142.1	B6D46_15660	B6D46_01230	Hypothetical protein.	Hypothetical protein.	0.991
OQY66026.1	OQY64893.1	B6D46_12400	B6D46_15660	Hypothetical protein.	Hypothetical protein.	0.989
OQY66026.1	OQY66678.1	B6D46_12400	B6D46_09460	Hypothetical protein.	Hypothetical protein.	0.988
OQY66026.1	OQY67576.1	B6D46_12400	B6D46_06000	Hypothetical protein.	Hypothetical protein.	0.985
OQY66026.1	OQY67943.1	B6D46_12400	B6D46_05170	Hypothetical protein.	Hypothetical protein.	0.930
OQY66026.1	OQY67953.1	B6D46_12400	B6D46_05220	Hypothetical protein.	Hypothetical protein.	0.977
OQY66026.1	OQY68019.1	B6D46_12400	B6D46_04915	Hypothetical protein.	Hypothetical protein.	0.971
OQY66026.1	OQY68459.1	B6D46_12400	B6D46_03430	Hypothetical protein.	Hypothetical protein.	0.977
OQY66026.1	OQY68820.1	B6D46_12400	B6D46_01615	Hypothetical protein.	Hypothetical protein.	0.937
OQY66026.1	OQY69097.1	B6D46_12400	B6D46_01005	Hypothetical protein.	Hypothetical protein.	0.948
OQY66026.1	OQY69142.1	B6D46_12400	B6D46_01230	Hypothetical protein.	Hypothetical protein.	0.930

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

49

average node degree:

8.91

avg. local clustering coefficient:

0.908

expected number of edges:

11

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000270

Peptidoglycan metabolic process

8 of 28

1.88

3.99

4.19e-11

GO:0009252

Peptidoglycan biosynthetic process

7 of 22

1.92

3.87

3.13e-10

GO:0071554

Cell wall organization or biogenesis

8 of 33

1.81

3.78

4.19e-11

GO:0008360

Regulation of cell shape

7 of 24

1.89

3.76

3.40e-10

GO:0071555

Cell wall organization

6 of 25

1.8

3.04

2.50e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016881

Acid-amino acid ligase activity

3 of 9

1.94

1.19

0.0049

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3311

Mixed, incl. Regulation of cell shape, and Cell cycle

11 of 43

1.83

5.15

1.93e-17

CL:3312

Mixed, incl. Regulation of cell shape, and Peptidoglycan muralytic activity

10 of 38

1.84

4.92

7.55e-16

CL:3376

Mixed, incl. Cell cycle protein, and Serine-type exopeptidase activity

4 of 5

2.32

3.15

6.65e-07

CL:3360

Regulation of cell shape, and Peptidoglycan muralytic activity

5 of 14

1.97

3.07

1.58e-07

CL:3317

Mur ligase, central, and Glycosylation

4 of 6

2.24

3.01

1.03e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00550

Peptidoglycan biosynthesis

6 of 25

1.8

2.97

4.46e-08

map00471

D-Glutamine and D-glutamate metabolism

2 of 4

2.12

1.04

0.0110

map01502

Vancomycin resistance

2 of 7

1.88

0.91

0.0175

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0961

Cell wall biogenesis/degradation

6 of 15

2.02

3.67

5.59e-09

KW-0132

Cell division

6 of 22

1.86

3.19

1.92e-08

KW-0131

Cell cycle

6 of 22

1.86

3.19

1.92e-08

KW-0573

Peptidoglycan synthesis

5 of 13

2.01

3.17

1.07e-07

KW-0436

Ligase

3 of 60

1.12

0.56

0.0449

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08245

Mur ligase middle domain

3 of 5

2.2

1.58

0.00097

PF03717

Penicillin-binding Protein dimerisation domain

2 of 2

2.42

0.97

0.0169

PF02875

Mur ligase family, glutamate ligase domain

2 of 3

2.24

0.93

0.0187

PF01225

Mur ligase family, catalytic domain

2 of 3

2.24

0.93

0.0187

PF00905

Penicillin binding protein transpeptidase domain

2 of 4

2.12

0.92

0.0187

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013221

Mur ligase, central

3 of 4

2.3

1.48

0.0017

IPR036615

Mur ligase, C-terminal domain superfamily

3 of 5

2.2

1.46

0.0017

IPR036565

Mur-like, catalytic domain superfamily

3 of 5

2.2

1.46

0.0017

IPR036138

Penicillin-binding protein, dimerisation domain superfamily

2 of 2

2.42

0.89

0.0232

IPR005311

Penicillin-binding protein, dimerisation domain

2 of 2

2.42

0.89

0.0232

(more ...)

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