Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
menB1,4-Dihydroxy-2-naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily. (305 aa)    
Predicted Functional Partners:
Noca_0508
PFAM: AMP-dependent synthetase and ligase; KEGG: tfu:Tfu_1408 putative ortho-succinylbenzoate-CoA synthetase.
 
 
 0.962
menD
2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
 
  
 0.875
menA
1,4-dihydroxy-2-naphtoate prenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily.
 
   
 0.821
Noca_0516
TIGRFAM: isochorismate synthases; PFAM: Anthranilate synthase component I and chorismate binding protein; KEGG: tfu:Tfu_1413 isochorismate synthase.
 
   
 0.735
menC
Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
 
   
 0.630
Noca_0257
PFAM: Mycobacterium tuberculosis paralogous family 11; KEGG: sma:SAV7465 hypothetical protein.
       0.569
Noca_0259
KEGG: cef:CE1017 hypothetical protein.
       0.559
Noca_3007
TIGRFAM: uncharacterized domain 1; PFAM: thioesterase superfamily protein; KEGG: sma:SAV6225 hypothetical protein.
 
   
 0.487
Noca_0256
Hypothetical protein.
       0.484
Noca_0862
PFAM: Enoyl-CoA hydratase/isomerase; KEGG: rha:RHA1_ro01928 probable enoyl-CoA hydratase.
 
   
 0.461
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614
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