Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nthEndonuclease III / DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (243 aa)    
Predicted Functional Partners:
Noca_1079
TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase; KEGG: tfu:Tfu_0258 AP endonuclease, family 1:exodeoxyribonuclease III xth.
  
 0.846
Noca_0343
PFAM: peptidase S1 and S6, chymotrypsin/Hap; Colicin V production protein; KEGG: fra:Francci3_4292 colicin V production protein.
   
 
 0.839
Noca_0342
PFAM: NUDIX hydrolase; KEGG: sma:SAV4594 hypothetical protein.
     
 0.828
Noca_0341
PFAM: Redoxin domain protein; KEGG: pac:PPA0224 hypothetical protein.
  
    0.816
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 
 0.753
Noca_0339
PFAM: cyclic nucleotide-binding; regulatory protein, Crp; KEGG: tfu:Tfu_0117 cyclic nucleotide-binding:bacterial regulatory protein, Crp.
 
   
 0.625
Noca_3933
PFAM: ExsB family protein; Haloacid dehalogenase domain protein hydrolase; PP-loop domain protein; KEGG: ade:Adeh_1542 hypothetical protein.
 
    0.620
ung
Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
  
 
 0.610
trpA
Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
  
  
 0.600
Noca_3128
DNA polymerase III, epsilon subunit; KEGG: fal:FRAAL5108 putative DNA-directed DNA polymerase; TIGRFAM: DNA polymerase III, epsilon subunit; PFAM: Excinuclease ABC, C subunit domain protein; UvrB/UvrC protein; Exonuclease, RNase T and DNA polymerase III; SMART: Exonuclease.
  
  
 0.599
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614
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