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nth protein (Nocardioides sp. JS614) - STRING interaction network
"nth" - Endonuclease III / DNA-(apurinic or apyrimidinic site) lyase in Nocardioides sp. JS614
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
nthEndonuclease III / DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3’ to the AP site by a beta-elimination, leaving a 3’-terminal unsaturated sugar and a product with a terminal 5’-phosphate (243 aa)    
Predicted Functional Partners:
Noca_1079
Exodeoxyribonuclease III (262 aa)
 
 
  0.971
Noca_0343
Peptidase S1 and S6, chymotrypsin/Hap (391 aa)
   
   
  0.914
Noca_0342
NUDIX hydrolase (239 aa)
   
 
  0.910
Noca_0341
Redoxin domain-containing protein (203 aa)
   
   
  0.892
Noca_0339
Cyclic nucleotide-binding protein (225 aa)
 
        0.812
Noca_3006
DNA polymerase I (889 aa)
   
 
  0.767
Noca_3128
Hypothetical protein (601 aa)
   
   
  0.683
Noca_4666
Endonuclease IV (269 aa)
   
 
  0.672
nfo
Endonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5’-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (294 aa)
   
 
  0.672
Noca_3301
DNA-3-methyladenine glycosylase II / transcriptional regulator Ada / DNA-O6-methylguanine--protein-cysteine S-methyltransferase (494 aa)
   
 
  0.604
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614, Nocardioides, Nocardioides JS614, Nocardioides sp. JS614
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