STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Noca_0377Sigma-70, region 4 type 2; PFAM: regulatory protein, LuxR; sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70, region 4 type 2; KEGG: sma:SAV6340 RNA polymerase ECF-subfamily sigma factor. (174 aa)    
Predicted Functional Partners:
Noca_0376
Hypothetical protein.
       0.773
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 
 0.589
Noca_0375
Hypothetical protein.
       0.538
Noca_3765
PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70, region 4 type 2; KEGG: sma:SAV4735 RNA polymerase ECF-subfamily sigma factor.
  
   
 0.537
Noca_1908
Sigma-70, region 4 type 2; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70, region 4 type 2; KEGG: tfu:Tfu_0842 putative RNA polymerase ECF-subfamily sigma factor.
  
     0.509
Noca_0488
KEGG: sma:SAV4734 hypothetical protein.
   
   0.490
Noca_0379
Transcriptional regulator, LacI family; PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator; KEGG: sco:SCO6349 transcriptional regulator.
  
  
 0.420
Noca_3673
Lipoprotein; KEGG: sma:SAV2224 lipoprotein.
 
 
 0.415
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.