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topA protein (Nocardioides sp. JS614) - STRING interaction network
"topA" - DNA topoisomerase I in Nocardioides sp. JS614
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5’-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3’-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA super [...] (905 aa)    
Predicted Functional Partners:
Noca_0133
DEAD/DEAH box helicase (714 aa)
   
  0.963
Noca_3006
DNA polymerase I (889 aa)
 
  0.892
Noca_0387
DNA polymerase III subunit delta’ (385 aa)
 
  0.890
recA
recA protein; Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (350 aa)
 
  0.881
Noca_2250
DNA primase catalytic core (1976 aa)
   
 
  0.856
Noca_1580
DNA primase catalytic core (1797 aa)
   
 
  0.856
rpoC
DNA-directed RNA polymerase subunit beta’; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (1290 aa)
     
 
  0.832
rpoA
DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (338 aa)
   
 
  0.821
Noca_2842
5’-3’ exonuclease (289 aa)
 
  0.788
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP (527 aa)
   
   
  0.775
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614, Nocardioides, Nocardioides JS614, Nocardioides sp. JS614
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