Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
disAProtein of unknown function DUF147; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. (360 aa)    
Predicted Functional Partners:
radA
DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.
  
  
 0.962
Noca_0300
KEGG: fal:FRAAL0085 hypothetical protein.
  
     0.699
Noca_1508
PFAM: UvrD/REP helicase; KEGG: sco:SCO5183 ATP-dependent DNA helicase; Belongs to the helicase family. UvrD subfamily.
   
    0.646
Noca_1509
PFAM: UvrD/REP helicase; KEGG: fra:Francci3_3799 UvrD/REP helicase; Belongs to the helicase family. UvrD subfamily.
   
    0.646
Noca_1885
TIGRFAM: degV family protein; PFAM: DegV family protein; KEGG: sma:SAV5490 hypothetical protein.
  
    0.496
Noca_3556
PFAM: 2',5' RNA ligase; KEGG: fal:FRAAL1171 putative secreted protein; putative phosphodiesterase domain.
 
     0.473
Noca_4038
PFAM: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; KEGG: mta:Moth_2487 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase.
  
    0.441
Noca_2716
PFAM: protein of unknown function DUF1290; KEGG: sco:SCO1386 integral membrane protein.
  
     0.425
Noca_2717
PFAM: protein of unknown function DUF881; KEGG: sco:SCO1387 membrane associated protein.
  
     0.414
Noca_0021
PFAM: protein of unknown function DUF881; KEGG: pac:PPA0183 membrane spanning protein DUF881.
  
     0.407
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614
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