STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Noca_0939KEGG: rha:RHA1_ro05843 probable cystathionine beta-synthase; TIGRFAM: cystathionine beta-synthase; PFAM: CBS domain containing protein; Pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (462 aa)    
Predicted Functional Partners:
Noca_0976
Cystathionine gamma-lyase; PFAM: aminotransferase, class V; Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: tfu:Tfu_0440 cystathionine gamma-synthase.
 
 0.993
Noca_3292
PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; KEGG: cgb:cg3086 putative L,L-cystathionine gamma-lyase.
 
 0.991
Noca_4306
TIGRFAM: serine O-acetyltransferase; KEGG: pfo:Pfl_4614 serine O-acetyltransferase.
 
 0.975
Noca_0979
L-threonine ammonia-lyase; TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit; amino acid-binding ACT domain protein; KEGG: sco:SCO4962 threonine dehydratase.
 
 
 0.969
Noca_3629
KEGG: bcl:ABC0432 O-acetylhomoserine (thiol)-lyase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes.
 
 
 0.957
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.951
Noca_2631
Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.951
Noca_2574
KEGG: sco:SCO1808 putative phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: amino acid-binding ACT domain protein; Haloacid dehalogenase domain protein hydrolase; Haloacid dehalogenase domain protein hydrolase, type 3.
    
 0.949
Noca_3943
Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; KEGG: sco:SCO1294 cystathionine gamma-synthase.
 
 0.945
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
 0.938
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614
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