STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Noca_2139Hypothetical protein. (98 aa)    
Predicted Functional Partners:
Noca_2136
PFAM: short-chain dehydrogenase/reductase SDR; KEGG: pfl:PFL_3855 cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase.
       0.773
Noca_2137
PFAM: Rieske [2Fe-2S] domain protein; KEGG: fal:FRAAL6167 hypothetical protein; putative dioxygenase.
       0.773
Noca_2138
PFAM: class II aldolase/adducin family protein; KEGG: mlo:mlr6791 similar to adducins.
       0.773
Noca_2134
PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: rha:RHA1_ro01381 possible ferredoxin--NAD(+) reductase.
       0.608
Noca_2135
PFAM: Rieske [2Fe-2S] domain protein; KEGG: sma:SAV6327 ferredoxin subunit of phenylpropionate dioxygenase.
       0.608
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
       0.536
Noca_2133
PFAM: regulatory proteins, IclR; KEGG: rha:RHA1_ro02487 transcriptional regulator, IclR family.
       0.434
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614
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