node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Noca_2447 | Noca_2448 | Noca_2447 | Noca_2448 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: sma:SAV6902 putative riboflavin synthase. | 0.999 |
Noca_2447 | hisE | Noca_2447 | Noca_2451 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: lxx:Lxx11210 phosphoribosyl-ATP pyrophosphatase. | 0.852 |
Noca_2447 | hisF | Noca_2447 | Noca_3039 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.487 |
Noca_2447 | hisG | Noca_2447 | Noca_2452 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.934 |
Noca_2448 | Noca_2447 | Noca_2448 | Noca_2447 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: sma:SAV6902 putative riboflavin synthase. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.999 |
Noca_2448 | hisC | Noca_2448 | Noca_3044 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: sma:SAV6902 putative riboflavin synthase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: tfu:Tfu_1151 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.429 |
Noca_2448 | hisE | Noca_2448 | Noca_2451 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: sma:SAV6902 putative riboflavin synthase. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: lxx:Lxx11210 phosphoribosyl-ATP pyrophosphatase. | 0.884 |
Noca_2448 | hisF | Noca_2448 | Noca_3039 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: sma:SAV6902 putative riboflavin synthase. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.412 |
Noca_2448 | hisG | Noca_2448 | Noca_2452 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: sma:SAV6902 putative riboflavin synthase. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.864 |
Noca_2448 | hisI | Noca_2448 | Noca_3032 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: sma:SAV6902 putative riboflavin synthase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.437 |
hisA | hisB | Noca_3040 | Noca_3043 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: tfu:Tfu_1155 bifunctional HisA/TrpF; TIGRFAM: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: blo:BL1297 imidazoleglycerol-phosphate dehydratase. | 0.998 |
hisA | hisC | Noca_3040 | Noca_3044 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: tfu:Tfu_1155 bifunctional HisA/TrpF; TIGRFAM: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: tfu:Tfu_1151 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.993 |
hisA | hisD | Noca_3040 | Noca_3045 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: tfu:Tfu_1155 bifunctional HisA/TrpF; TIGRFAM: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.998 |
hisA | hisE | Noca_3040 | Noca_2451 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: tfu:Tfu_1155 bifunctional HisA/TrpF; TIGRFAM: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis. | PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: lxx:Lxx11210 phosphoribosyl-ATP pyrophosphatase. | 0.978 |
hisA | hisF | Noca_3040 | Noca_3039 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: tfu:Tfu_1155 bifunctional HisA/TrpF; TIGRFAM: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | Noca_3040 | Noca_2452 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: tfu:Tfu_1155 bifunctional HisA/TrpF; TIGRFAM: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis. | ATP phosphoribosyltransferase (homohexameric); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.993 |
hisA | hisH | Noca_3040 | Noca_3042 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: tfu:Tfu_1155 bifunctional HisA/TrpF; TIGRFAM: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | Noca_3040 | Noca_3032 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: tfu:Tfu_1155 bifunctional HisA/TrpF; TIGRFAM: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisB | hisA | Noca_3043 | Noca_3040 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: blo:BL1297 imidazoleglycerol-phosphate dehydratase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; KEGG: tfu:Tfu_1155 bifunctional HisA/TrpF; TIGRFAM: bifunctional HisA/TrpF protein; PFAM: histidine biosynthesis. | 0.998 |
hisB | hisC | Noca_3043 | Noca_3044 | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: blo:BL1297 imidazoleglycerol-phosphate dehydratase. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: tfu:Tfu_1151 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |