STRINGSTRING
pup protein (Nocardioides sp. JS614) - STRING interaction network
"pup" - Hypothetical protein in Nocardioides sp. JS614
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pupHypothetical protein; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (65 aa)    
Predicted Functional Partners:
prcA
20S proteasome, A and B subunits; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (255 aa)
 
          0.939
prcB
Proteasome subunit beta; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (283 aa)
 
          0.935
Noca_2643
Hypothetical protein (502 aa)
 
          0.933
pafA
Hypothetical protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (453 aa)
 
          0.792
arc
Vesicle-fusing ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a ’key in a lock’ to induce gate opening and therefore regulate proteolysis (584 aa)
 
          0.676
Noca_2642
Type 11 methyltransferase (208 aa)
              0.617
Noca_2641
YbaK/prolyl-tRNA synthetase associated domain-containing protein (161 aa)
              0.611
Noca_2626
Hypothetical protein (191 aa)
   
          0.597
Noca_3198
N-acetyltransferase GCN5 (281 aa)
   
          0.589
Noca_2647
Hypothetical protein (337 aa)
              0.558
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614, Nocardioides, Nocardioides JS614, Nocardioides sp. JS614
Server load: low (12%) [HD]