STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nfoEndonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin. (294 aa)    
Predicted Functional Partners:
Noca_4666
KEGG: mbo:Mb0689 endonuclease IV; PFAM: Xylose isomerase domain protein TIM barrel; SMART: AP endonuclease, family 2.
  
  
 
0.927
Noca_3091
PFAM: protein of unknown function DUF6, transmembrane; KEGG: pac:PPA0728 membrane spanning protein DUF6.
  
    0.793
Noca_1079
TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase; KEGG: tfu:Tfu_0258 AP endonuclease, family 1:exodeoxyribonuclease III xth.
   
 
 0.690
nth
Endonuclease III / DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
  
 
 0.530
Noca_2013
PFAM: protein of unknown function DUF34; KEGG: rha:RHA1_ro01183 hypothetical protein; Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
     
 0.467
pyrF
TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; KEGG: sma:SAV6869 putative orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily.
     
 0.454
Noca_3092
3-deoxy-D-arabinoheptulosonate-7-phosphate synthase; TIGRFAM: phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA; KEGG: tfu:Tfu_1039 phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2.
       0.454
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 
 0.450
Noca_2964
PFAM: HhH-GPD family protein; KEGG: mbo:Mb1187 hypothetical protein.
  
 
 0.443
Noca_1640
PFAM: protein of unknown function DUF323; KEGG: bbr:BB1966 hypothetical protein.
      
 0.440
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614
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