STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Noca_3301DNA-O6-methylguanine--protein-cysteine S-methyltransferase / DNA-3-methyladenine glycosylase II; PFAM: helix-turn-helix- domain containing protein, AraC type; HhH-GPD family protein; Ada, metal-binding domain protein; AlkA domain protein; KEGG: sco:SCO6461 putative ADA-like regulatory protein. (494 aa)    
Predicted Functional Partners:
Noca_3300
methylated-DNA--protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
  
 0.973
Noca_1079
TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase; KEGG: tfu:Tfu_0258 AP endonuclease, family 1:exodeoxyribonuclease III xth.
  
 0.891
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 
 0.845
Noca_3810
PFAM: BRCT domain protein; Exonuclease, RNase T and DNA polymerase III; SMART: Exonuclease; KEGG: tfu:Tfu_0714 exonuclease.
  
  
 0.791
Noca_1887
TIGRFAM: DNA internalization-related competence protein ComEC/Rec2; PFAM: beta-lactamase domain protein; ComEC/Rec2-related protein; KEGG: sco:SCO2567 integral membrane protein.
     
 0.725
Noca_3962
DNA-N1-methyladenine dioxygenase; KEGG: sma:SAV1131 alkylated DNA repair protein.
  
  
 0.695
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.665
Noca_0664
PFAM: methyladenine glycosylase; KEGG: cef:CE2657 putative 3-methyladenine-DNA glycosylase.
     
 0.608
Noca_1896
KEGG: rha:RHA1_ro06213 possible DNA-directed DNA polymerase.
 
 
 0.608
Noca_3128
DNA polymerase III, epsilon subunit; KEGG: fal:FRAAL5108 putative DNA-directed DNA polymerase; TIGRFAM: DNA polymerase III, epsilon subunit; PFAM: Excinuclease ABC, C subunit domain protein; UvrB/UvrC protein; Exonuclease, RNase T and DNA polymerase III; SMART: Exonuclease.
  
  
 0.588
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614
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