STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Noca_3404TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; KEGG: sma:SAV6094 thiamine biosynthesis ThiS. (62 aa)    
Predicted Functional Partners:
Noca_3403
Thiazole-phosphate synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
  
 
 0.996
thiC
Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 0.972
Noca_3401
KEGG: rme:Rmet_0169 phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1.
  
  
 0.965
Noca_3402
PFAM: thiamine monophosphate synthase; KEGG: pca:Pcar_0607 thiamine-phosphate pyrophosphorylase.
  
  
 0.956
thiE
Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
  
 0.956
Noca_1474
PFAM: UBA/THIF-type NAD/FAD binding protein; Rhodanese domain protein; MoeZ/MoeB domain protein; KEGG: sma:SAV3082 molybdopterin biosynthesis protein MoeB.
  
 
 0.952
Noca_3405
TIGRFAM: glycine oxidase ThiO; PFAM: FAD dependent oxidoreductase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: sco:SCO2107 putative oxidoreductase.
  
  
 0.883
Noca_1310
PFAM: Mov34/MPN/PAD-1 family protein; KEGG: sma:SAV5162 hypothetical protein.
  
 
 0.793
Noca_0814
FO synthase subunit 1; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: nfa:nfa47520 hypothetical protein.
  
  
 0.681
Noca_0863
FO synthase subunit 1; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: fra:Francci3_0745 conserved hypothetical protein.
  
  
 0.681
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614
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