Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
Noca_3455PFAM: major facilitator superfamily MFS_1; KEGG: tfu:Tfu_1375 putative integral membrane transporter. (369 aa)    
Predicted Functional Partners:
Noca_2016
PFAM: protein of unknown function DUF328; KEGG: sco:SCO2297 hypothetical protein; Belongs to the UPF0246 family.
 
    0.845
Noca_3453
KEGG: sma:SAV5464 hypothetical protein.
       0.530
Noca_3454
KEGG: mmc:Mmcs_2986 hypothetical protein.
       0.527
Noca_3458
PFAM: NUDIX hydrolase; KEGG: mmc:Mmcs_4021 NUDIX hydrolase.
       0.517
Noca_3456
Hypothetical protein.
       0.506
Noca_3457
PFAM: CopG domain protein DNA-binding domain protein.
       0.506
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
    0.412
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614
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