STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
sucDsuccinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (297 aa)    
Predicted Functional Partners:
sucC
succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 0.999
Noca_1737
TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: dehydrogenase, E1 component; catalytic domain of components of various dehydrogenase complexes; Transketolase, central region; KEGG: sco:SCO5281 putative 2-oxoglutarate dehydrogenase.
 
 
 0.978
Noca_3547
TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; PFAM: ferredoxin; KEGG: rha:RHA1_ro01048 succinate dehydrogenase iron-sulfur protein.
 
 0.976
Noca_3553
TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; KEGG: tfu:Tfu_2451 putative succinate dehydrogenase iron-sulfur protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
  
 0.969
Noca_2303
2-oxoglutarate dehydrogenase E2 component; PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein; KEGG: rha:RHA1_ro01151 probable dihydrolipoyllysine-residue succinyltransferase.
  
 0.968
Noca_3548
PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD dependent oxidoreductase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: mpa:MAP3698c probable succinate dehydrogenase.
 
 0.967
Noca_3552
KEGG: tfu:Tfu_2452 succinate dehydrogenase or fumarate reductase, flavoprotein subunit, low-GC gram-positive bacteria; TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein.
  
 0.951
Noca_3591
isobutyryl-CoA mutase small subunit; PFAM: cobalamin B12-binding domain protein; KEGG: sco:SCO4800 isobutiryl CoA mutase, small subunit.
    
 0.949
Noca_0537
PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: tfu:Tfu_2674 2-oxoglutarate ferredoxin oxidoreductase, alpha subunit.
  
 
 0.947
Noca_0198
PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; KEGG: sil:SPO1469 3-ketosteroid dehydrogenase, putative.
  
 0.945
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.