Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Noca_3933PFAM: ExsB family protein; Haloacid dehalogenase domain protein hydrolase; PP-loop domain protein; KEGG: ade:Adeh_1542 hypothetical protein. (472 aa)    
Predicted Functional Partners:
Noca_0169
KEGG: syc:syc0382_d circadian phase modifier CpmA.
 
  
 0.944
larC
Protein of unknown function DUF111; Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes. Belongs to the LarC family.
  
 0.930
Noca_2000
KEGG: rxy:Rxyl_2107 hypothetical protein.
 
  
 0.886
Noca_1327
PFAM: cobalamin (vitamin B12) biosynthesis CbiM protein; KEGG: sma:SAV3606 putative membrane protein.
 
    0.714
Noca_3932
PFAM: Cold-shock protein, DNA-binding; SMART: Cold shock protein; KEGG: pac:PPA0477 cold shock protein.
       0.673
Noca_1328
KEGG: sma:SAV3606 putative membrane protein.
  
    0.645
moaA
GTP cyclohydrolase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.
  
    0.628
moaA-2
GTP cyclohydrolase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.
  
    0.628
nth
Endonuclease III / DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
 
    0.620
Noca_3107
PFAM: LOR/SDH bifunctional enzyme conserved domain protein; KEGG: fal:FRAAL5090 hypothetical protein.
 
     0.610
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614
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