Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mshAGlycosyl transferase, group 1; Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2- deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway. (458 aa)    
Predicted Functional Partners:
Noca_4049
KEGG: sco:SCO4205 hypothetical protein.
 
     0.842
Noca_4051
Hypothetical protein.
       0.773
mca
LmbE family protein; A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S- conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics; Belongs to the MshB deacetylase family. Mca subfamily.
 
  
 0.677
Noca_4678
PFAM: Myo-inositol-1-phosphate synthase; Myo-inositol-1-phosphate synthase, GAPDH domain protein; KEGG: tfu:Tfu_3099 myo-inositol-1-phosphate synthase.
 
 
 0.671
mshB
LmbE family protein; Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2- deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.
  
 0.655
Noca_0267
Maltooligosyl trehalose hydrolase; KEGG: nfa:nfa18050 putative glycosyl hydrolase; TIGRFAM: malto-oligosyltrehalose trehalohydrolase; PFAM: alpha amylase, catalytic region; SMART: alpha amylase, catalytic sub domain.
   
 0.631
glgB
1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
   
 0.624
mshD
GCN5-related N-acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.
  
   
 0.612
Noca_1383
KEGG: mmc:Mmcs_3603 DsbA oxidoreductase.
  
     0.588
Noca_1516
ATP-dependent DNA helicase, Rep family; PFAM: UvrD/REP helicase; HRDC domain protein; KEGG: sco:SCO5188 putative ATP-dependent DNA helicase.
   
 
 0.587
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614
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