Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Noca_4462PFAM: bifunctional deaminase-reductase domain protein; KEGG: cvi:CV3295 hypothetical protein. (202 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
  
 0.697
Noca_3842
KEGG: mmc:Mmcs_0215 bifunctional deaminase-reductase-like protein.
 
     0.589
Noca_4463
PFAM: major facilitator superfamily MFS_1; KEGG: sma:SAV4232 hypothetical protein.
   
 
 0.575
Noca_0278
PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: lxx:Lxx15560 lyase.
 
  
 0.502
Noca_1274
Transcriptional regulator, ArsR family; PFAM: regulatory protein, ArsR; KEGG: mlo:mll3559 probable transcription regulator.
 
     0.497
clpX
ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
   
 
 0.490
Noca_3394
PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: pol:Bpro_0156 glyoxalase/bleomycin resistance protein/dioxygenase.
 
  
 0.477
Noca_4374
KEGG: sco:SCO0378 conserved secreted protein.
  
     0.466
Noca_3869
RNA polymerase, sigma subunit, ECF family; PFAM: sigma-70 region 2 domain protein; Sigma-70, region 4 type 2; KEGG: sco:SCO4452 RNA polymerase sigma factor.
 
     0.417
pheT
TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; KEGG: sma:SAV6743 putative phenylalanyl-tRNA synthetase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
  
  
 0.416
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614
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