Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Noca_4570PFAM: glutamine amidotransferase class-I; KEGG: jan:Jann_1856 glutamine amidotransferase class-I. (243 aa)    
Predicted Functional Partners:
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
 0.973
Noca_2608
IMP dehydrogenase family protein; KEGG: sma:SAV6884 putative inosine monophosphate dehydrogenase; TIGRFAM: IMP dehydrogenase family protein; PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase.
  
 
 0.957
Noca_3640
TIGRFAM: IMP dehydrogenase family protein; PFAM: IMP dehydrogenase/GMP reductase; KEGG: sma:SAV5001 putative inosine-5'-monophosphate dehydrogenase.
  
 
 0.939
Noca_2322
PFAM: Endonuclease/exonuclease/phosphatase; KEGG: cjk:jk1043 putative extracellular nuclease.
 
  
  0.936
Noca_0829
PFAM: glutamine amidotransferase class-I; KEGG: sai:Saci_1154 hypothetical protein.
  
  
  0.926
Noca_1324
Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
 
 
 0.920
Noca_2047
PFAM: glutamine amidotransferase class-I; KEGG: sco:SCO0603 amino transferase.
  
  
 
0.918
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
  
 
 0.918
Noca_0443
KEGG: sco:SCO3405 putative hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.917
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
 
  
0.914
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614
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