STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Noca_4666KEGG: mbo:Mb0689 endonuclease IV; PFAM: Xylose isomerase domain protein TIM barrel; SMART: AP endonuclease, family 2. (269 aa)    
Predicted Functional Partners:
nfo
Endonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.
  
  
 
0.927
Noca_4667
KEGG: sco:SCO4220 hypothetical protein.
       0.773
Noca_1079
TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase; KEGG: tfu:Tfu_0258 AP endonuclease, family 1:exodeoxyribonuclease III xth.
   
 
 0.690
Noca_3128
DNA polymerase III, epsilon subunit; KEGG: fal:FRAAL5108 putative DNA-directed DNA polymerase; TIGRFAM: DNA polymerase III, epsilon subunit; PFAM: Excinuclease ABC, C subunit domain protein; UvrB/UvrC protein; Exonuclease, RNase T and DNA polymerase III; SMART: Exonuclease.
 
   
 0.536
nth
Endonuclease III / DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
  
 
 0.530
Noca_2964
PFAM: HhH-GPD family protein; KEGG: mbo:Mb1187 hypothetical protein.
 
 
 0.524
Noca_4672
PFAM: sigma-70 region 2 domain protein; KEGG: sco:SCO6996 RNA polymerase sigma factor; Belongs to the sigma-70 factor family. ECF subfamily.
  
     0.485
Noca_2013
PFAM: protein of unknown function DUF34; KEGG: rha:RHA1_ro01183 hypothetical protein; Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
     
 0.467
Noca_4670
PFAM: peptidase S8 and S53, subtilisin, kexin, sedolisin; KEGG: sco:SCO6995 protease.
  
     0.455
pyrF
TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase; KEGG: sma:SAV6869 putative orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily.
     
 0.454
Your Current Organism:
Nocardioides sp. JS614
NCBI taxonomy Id: 196162
Other names: N. sp. JS614
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