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Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
vgbVirginiamycin B lyase; Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2- amino-butenoic acid. (306 aa)    
Predicted Functional Partners:
KUN46167.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.701
KUN46169.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.680
dapA2
4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
     
 0.612
KUN46170.1
Deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.584
KUN44192.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.579
KUN47156.1
Cholesterol oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.537
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
      
 0.529
KUN45464.1
Ammonia channel protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.524
KUN46166.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.515
KUN43321.1
Penicillin amidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
      
 0.510
Your Current Organism:
Streptomyces olivochromogenes
NCBI taxonomy Id: 1963
Other names: ATCC 25479, ATCC 3336, Actinomyces olivochromogenus, CBS 889.69, DSM 40451, IFO 13067, IFO 3178, IMET 40352, ISP 5451, JCM 4163, JCM 4500, KCTC 9064, NBRC 13067, NBRC 3178, NRRL-ISP 5451, S. olivochromogenes, Streptomyces olivichromogenes, Streptomyces olivochromogenus
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