STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metYO-Acetylhomoserine (Thiol)-Lyase; Catalyzes the conversion of O-acetyl-L-homoserine (OAH) into homocysteine in the methionine biosynthesis pathway (Ref.4,. Can also use dimethyldisulfide and methanethiol as reduced sulfur sources, leading to the direct formation of methionine. Has weak cystathionine gamma-synthase activity. (437 aa)    
Predicted Functional Partners:
metX
Homoserine O-Acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the AB hydrolase superfamily. MetX family.
 
 0.999
Cgl0839
Alpha/beta hydrolase fold; Belongs to the AB hydrolase superfamily. MetX family.
 
 
 0.997
metE
Homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 
 0.975
metH
Homocysteine Methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.973
aecD
Cystathionine beta-Lyase.
   
 0.972
Cgl2786
Putative L,L-Cystathionine gamma-Lyase.
 
 
0.953
cysJ
Probable Sulfite Reductase (Flavoprotein).
   
 
 0.952
metB
Cystathionine gamma-Synthase.
 
 
0.948
sahH
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
   
 
 0.937
cysK
O-Acetylserine (Thiol)-Lyase; Belongs to the cysteine synthase/cystathionine beta- synthase family.
 
 
 0.931
Your Current Organism:
Corynebacterium glutamicum
NCBI taxonomy Id: 196627
Other names: C. glutamicum ATCC 13032, Corynebacterium glutamicum ATCC 13032, Corynebacterium glutamicum str. ATCC 13032, Corynebacterium glutamicum strain ATCC 13032
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