node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cgl0328 | guaA | cg0397 | cg0703 | PROBABLE 5'-NUCLEOTIDASE PRECURSOR; Belongs to the 5'-nucleotidase family. | PUTATIVE GMP SYNTHASE; Catalyzes the synthesis of GMP from XMP. | 0.908 |
Cgl0328 | pyrF | cg0397 | cg1812 | PROBABLE 5'-NUCLEOTIDASE PRECURSOR; Belongs to the 5'-nucleotidase family. | Orotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.900 |
Cgl0328 | pyrH | cg0397 | cg2218 | PROBABLE 5'-NUCLEOTIDASE PRECURSOR; Belongs to the 5'-nucleotidase family. | UMP-KINASE; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.900 |
Cgl0328 | pyrR | cg0397 | cg1817 | PROBABLE 5'-NUCLEOTIDASE PRECURSOR; Belongs to the 5'-nucleotidase family. | Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase; Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines. | 0.900 |
Cgl0328 | upp | cg0397 | cg0786 | PROBABLE 5'-NUCLEOTIDASE PRECURSOR; Belongs to the 5'-nucleotidase family. | PUTATIVE URACIL PHOSPHORIBOSYLTRANSFERASE; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.900 |
codA | pyrR | cg0104 | cg1817 | CREATININE DEAMINASE. | Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase; Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines. | 0.903 |
codA | upp | cg0104 | cg0786 | CREATININE DEAMINASE. | PUTATIVE URACIL PHOSPHORIBOSYLTRANSFERASE; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.927 |
glyA | guaA | cg1133 | cg0703 | Serine Hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | PUTATIVE GMP SYNTHASE; Catalyzes the synthesis of GMP from XMP. | 0.580 |
glyA | pyrF | cg1133 | cg1812 | Serine Hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Orotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.499 |
glyA | rpi | cg1133 | cg2658 | Serine Hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | POSSIBLE PHOSPHOPENTOSE ISOMERASE. | 0.927 |
glyA | upp | cg1133 | cg0786 | Serine Hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | PUTATIVE URACIL PHOSPHORIBOSYLTRANSFERASE; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.790 |
guaA | Cgl0328 | cg0703 | cg0397 | PUTATIVE GMP SYNTHASE; Catalyzes the synthesis of GMP from XMP. | PROBABLE 5'-NUCLEOTIDASE PRECURSOR; Belongs to the 5'-nucleotidase family. | 0.908 |
guaA | glyA | cg0703 | cg1133 | PUTATIVE GMP SYNTHASE; Catalyzes the synthesis of GMP from XMP. | Serine Hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.580 |
guaA | pyrF | cg0703 | cg1812 | PUTATIVE GMP SYNTHASE; Catalyzes the synthesis of GMP from XMP. | Orotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.520 |
guaA | pyrH | cg0703 | cg2218 | PUTATIVE GMP SYNTHASE; Catalyzes the synthesis of GMP from XMP. | UMP-KINASE; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.753 |
guaA | pyrR | cg0703 | cg1817 | PUTATIVE GMP SYNTHASE; Catalyzes the synthesis of GMP from XMP. | Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase; Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines. | 0.435 |
guaA | rpsL | cg0703 | cg0581 | PUTATIVE GMP SYNTHASE; Catalyzes the synthesis of GMP from XMP. | RIBOSOMAL PROTEIN S12; With S4 and S5 plays an important role in translational accuracy. | 0.788 |
guaA | upp | cg0703 | cg0786 | PUTATIVE GMP SYNTHASE; Catalyzes the synthesis of GMP from XMP. | PUTATIVE URACIL PHOSPHORIBOSYLTRANSFERASE; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.853 |
pyrF | Cgl0328 | cg1812 | cg0397 | Orotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | PROBABLE 5'-NUCLEOTIDASE PRECURSOR; Belongs to the 5'-nucleotidase family. | 0.900 |
pyrF | glyA | cg1812 | cg1133 | Orotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | Serine Hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.499 |