node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cgl2129 | hom | cg2337 | cg1337 | Similar to methionine synthase II (cobalamin-independent). | Homoserine Dehydrogenase; Belongs to the homoserine dehydrogenase family. | 0.856 |
Cgl2129 | ilvA | cg2337 | cg2334 | Similar to methionine synthase II (cobalamin-independent). | THREONINE DEHYDRATASE; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). | 0.882 |
Cgl2129 | metB | cg2337 | cg2687 | Similar to methionine synthase II (cobalamin-independent). | Cystathionine gamma-Synthase. | 0.942 |
Cgl2129 | metE | cg2337 | cg1290 | Similar to methionine synthase II (cobalamin-independent). | Homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.913 |
Cgl2129 | metH | cg2337 | cg1701 | Similar to methionine synthase II (cobalamin-independent). | Homocysteine Methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.971 |
Cgl2129 | thrB | cg2337 | cg1338 | Similar to methionine synthase II (cobalamin-independent). | Homoserine Kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.865 |
hom | Cgl2129 | cg1337 | cg2337 | Homoserine Dehydrogenase; Belongs to the homoserine dehydrogenase family. | Similar to methionine synthase II (cobalamin-independent). | 0.856 |
hom | ilvA | cg1337 | cg2334 | Homoserine Dehydrogenase; Belongs to the homoserine dehydrogenase family. | THREONINE DEHYDRATASE; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). | 0.973 |
hom | ilvE | cg1337 | cg2418 | Homoserine Dehydrogenase; Belongs to the homoserine dehydrogenase family. | BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE. | 0.903 |
hom | lysC | cg1337 | cg0306 | Homoserine Dehydrogenase; Belongs to the homoserine dehydrogenase family. | ASPARTOKINASE LYSC ALPHA and beta SUBUNITs; Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine; Belongs to the aspartokinase family. | 0.998 |
hom | metB | cg1337 | cg2687 | Homoserine Dehydrogenase; Belongs to the homoserine dehydrogenase family. | Cystathionine gamma-Synthase. | 0.911 |
hom | metE | cg1337 | cg1290 | Homoserine Dehydrogenase; Belongs to the homoserine dehydrogenase family. | Homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.884 |
hom | metH | cg1337 | cg1701 | Homoserine Dehydrogenase; Belongs to the homoserine dehydrogenase family. | Homocysteine Methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.959 |
hom | thrB | cg1337 | cg1338 | Homoserine Dehydrogenase; Belongs to the homoserine dehydrogenase family. | Homoserine Kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.999 |
hom | thrC | cg1337 | cg2437 | Homoserine Dehydrogenase; Belongs to the homoserine dehydrogenase family. | THREONINE SYNTHASE; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. | 0.997 |
ilvA | Cgl2129 | cg2334 | cg2337 | THREONINE DEHYDRATASE; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). | Similar to methionine synthase II (cobalamin-independent). | 0.882 |
ilvA | hom | cg2334 | cg1337 | THREONINE DEHYDRATASE; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). | Homoserine Dehydrogenase; Belongs to the homoserine dehydrogenase family. | 0.973 |
ilvA | ilvE | cg2334 | cg2418 | THREONINE DEHYDRATASE; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). | BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE. | 0.995 |
ilvA | lysC | cg2334 | cg0306 | THREONINE DEHYDRATASE; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). | ASPARTOKINASE LYSC ALPHA and beta SUBUNITs; Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine; Belongs to the aspartokinase family. | 0.729 |
ilvA | metB | cg2334 | cg2687 | THREONINE DEHYDRATASE; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). | Cystathionine gamma-Synthase. | 0.838 |