STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
lysELysine efflux permease; Catalyzes the efflux of L-lysine. Can also export L- arginine and L-citrulline. The lysEG system prevents bacteriostasis due to elevated L-lysine or L-arginine concentrations that arise during growth in the presence of peptides or in mutants possessing a deregulated biosynthesis pathway. In vitro, can also export D-lysine during biotechnological production of D-amino acids. (233 aa)    
Predicted Functional Partners:
lysG
TRANSCRIPTIONAL REGULATOR, LYSR FAMILY; Positively regulates the expression of the exporter LysE. Induction requires the presence of a coinducer, which is either intracellular L-lysine, L-arginine or L-citrulline. L-histidine also acts as coinducer of lysE expression, but this amino acid is not exported by LysE. The lysEG system prevents bacteriostasis due to elevated L-lysine or L-arginine concentrations that arise during growth in the presence of peptides or in mutants possessing a deregulated biosynthesis pathway ; Belongs to the LysR transcriptional regulatory family.
 
  
 0.994
thrE
THREONINE EXPORT CARRIER.
  
  
 0.822
putP
PROLINE TRANSPORT SYSTEM; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
      
 0.792
yggB
Small-conductance mechanosensitive channel.
      
 0.776
argR
ARGININE REPRESSOR; Regulates arginine biosynthesis genes.
      
 0.700
Cgl2611
Permease of the major facilitator superfamily.
   
  
 0.683
lysC
ASPARTOKINASE LYSC ALPHA and beta SUBUNITs; Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine; Belongs to the aspartokinase family.
      
 0.640
brnQ
Branched-Chain Amino Acid Uptake Carrier; Component of the transport system for branched-chain amino acids (leucine, isoleucine and valine) Which is coupled to a proton motive force.
      
 0.639
argF
ORNITHINE CARBAMOYLTRANSFERASE; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
      
 0.635
ddh
MESO-DIAMINOPIMELATE DEHYDROGENASE; Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate. Probably plays a role in lysine biosynthesis. Exhibits a high substrate specificity for meso-2,6-diaminopimelate, since L,L- 2,6-diaminopimelate, D,D-2,6-diaminopimelate, L-glutamate, L-alanine, L-leucine, L-valine, L-aspartate, L-threonine, L-homoserine, L- methionine, L-lysine, L-serine, L-phenylalanine, L-tyrosine, L- tryptophan, L-ornithine, L-histidine, L- [...]
      
 0.620
Your Current Organism:
Corynebacterium glutamicum
NCBI taxonomy Id: 196627
Other names: C. glutamicum ATCC 13032, Corynebacterium glutamicum ATCC 13032, Corynebacterium glutamicum str. ATCC 13032, Corynebacterium glutamicum strain ATCC 13032
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