node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cgl1314 | leuB | cg1486 | cg1453 | Bacterial regulatory proteins, IclR family. | 3-ISOPROPYLMALATE DEHYDROGENASE; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity); Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.741 |
Cgl1314 | leuC | cg1486 | cg1487 | Bacterial regulatory proteins, IclR family. | 3-ISOPROPYLMALATE DEHYDRATASE LARGE SUBUNIT; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily. | 0.979 |
Cgl1314 | leuD | cg1486 | cg1488 | Bacterial regulatory proteins, IclR family. | 3-ISOPROPYLMALATE DEHYDRATASE (SMALL SUBUNIT); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.842 |
Cgl2910 | ilvN | cg3218 | cg1436 | PYRUVATE KINASE-LIKE PROTEIN. | ACETOHYDROXYACID SYNTHASE SMALL SUBUNIT. | 0.800 |
Cgl2910 | ldh | cg3218 | cg3219 | PYRUVATE KINASE-LIKE PROTEIN. | L-LACTATE DEHYDROGENASE; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. | 0.989 |
Cgl2910 | leuA | cg3218 | cg0303 | PYRUVATE KINASE-LIKE PROTEIN. | 2-ISOPROPYLMALATE SYNTHASE; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.810 |
Cgl2910 | leuC | cg3218 | cg1487 | PYRUVATE KINASE-LIKE PROTEIN. | 3-ISOPROPYLMALATE DEHYDRATASE LARGE SUBUNIT; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily. | 0.808 |
Cgl2910 | leuD | cg3218 | cg1488 | PYRUVATE KINASE-LIKE PROTEIN. | 3-ISOPROPYLMALATE DEHYDRATASE (SMALL SUBUNIT); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.809 |
Cgl2910 | poxB | cg3218 | cg2891 | PYRUVATE KINASE-LIKE PROTEIN. | PYRUVATE DEHYDROGENASE; Belongs to the TPP enzyme family. | 0.919 |
ilvC | ilvD | cg1437 | cg1432 | KETOL-ACID REDUCTOISOMERASE; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | DIHYDROXY-ACID DEHYDRATASE; Belongs to the IlvD/Edd family. | 0.999 |
ilvC | ilvN | cg1437 | cg1436 | KETOL-ACID REDUCTOISOMERASE; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | ACETOHYDROXYACID SYNTHASE SMALL SUBUNIT. | 0.999 |
ilvC | ldh | cg1437 | cg3219 | KETOL-ACID REDUCTOISOMERASE; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | L-LACTATE DEHYDROGENASE; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. | 0.429 |
ilvC | leuA | cg1437 | cg0303 | KETOL-ACID REDUCTOISOMERASE; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 2-ISOPROPYLMALATE SYNTHASE; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.976 |
ilvC | leuB | cg1437 | cg1453 | KETOL-ACID REDUCTOISOMERASE; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 3-ISOPROPYLMALATE DEHYDROGENASE; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity); Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.979 |
ilvC | leuC | cg1437 | cg1487 | KETOL-ACID REDUCTOISOMERASE; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 3-ISOPROPYLMALATE DEHYDRATASE LARGE SUBUNIT; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily. | 0.987 |
ilvC | leuD | cg1437 | cg1488 | KETOL-ACID REDUCTOISOMERASE; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 3-ISOPROPYLMALATE DEHYDRATASE (SMALL SUBUNIT); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.963 |
ilvC | poxB | cg1437 | cg2891 | KETOL-ACID REDUCTOISOMERASE; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | PYRUVATE DEHYDROGENASE; Belongs to the TPP enzyme family. | 0.509 |
ilvD | ilvC | cg1432 | cg1437 | DIHYDROXY-ACID DEHYDRATASE; Belongs to the IlvD/Edd family. | KETOL-ACID REDUCTOISOMERASE; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.999 |
ilvD | ilvN | cg1432 | cg1436 | DIHYDROXY-ACID DEHYDRATASE; Belongs to the IlvD/Edd family. | ACETOHYDROXYACID SYNTHASE SMALL SUBUNIT. | 0.935 |
ilvD | ldh | cg1432 | cg3219 | DIHYDROXY-ACID DEHYDRATASE; Belongs to the IlvD/Edd family. | L-LACTATE DEHYDROGENASE; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. | 0.437 |