node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cgl0120 | cynT | cg0155 | cg2954 | PUTATIVE ACETYLTRANSFERASE. | CARBONIC ANHYDRASE. | 0.992 |
Cgl0120 | mutY | cg0155 | cg2955 | PUTATIVE ACETYLTRANSFERASE. | A/G-SPECIFIC ADENINE GLYCOSYLASE. | 0.780 |
cynT | Cgl0120 | cg2954 | cg0155 | CARBONIC ANHYDRASE. | PUTATIVE ACETYLTRANSFERASE. | 0.992 |
cynT | mutY | cg2954 | cg2955 | CARBONIC ANHYDRASE. | A/G-SPECIFIC ADENINE GLYCOSYLASE. | 0.931 |
mutM1 | mutY | cg2272 | cg2955 | FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | A/G-SPECIFIC ADENINE GLYCOSYLASE. | 0.984 |
mutM1 | ogt | cg2272 | cg3331 | FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. | 0.640 |
mutM1 | radA | cg2272 | cg2950 | FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | PROBABLE ATP-DEPENDENT PROTEASE, DNA REPAIR (ATP-B; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. | 0.740 |
mutM1 | recN | cg2272 | cg1602 | FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | DNA REPAIR PROTEIN RECN; May be involved in recombinational repair of damaged DNA. | 0.754 |
mutM1 | recO | cg2272 | cg2509 | FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | Recombinational DNA repair protein (RecF pathway); Involved in DNA repair and RecF pathway recombination. | 0.709 |
mutM1 | ruvB | cg2272 | cg1869 | FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | Holliday junction resolvasome helicase subunit; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. | 0.770 |
mutM1 | uvrB | cg2272 | cg1550 | FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | EXCINUCLEASE ABC SUBUNIT B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.844 |
mutY | Cgl0120 | cg2955 | cg0155 | A/G-SPECIFIC ADENINE GLYCOSYLASE. | PUTATIVE ACETYLTRANSFERASE. | 0.780 |
mutY | cynT | cg2955 | cg2954 | A/G-SPECIFIC ADENINE GLYCOSYLASE. | CARBONIC ANHYDRASE. | 0.931 |
mutY | mutM1 | cg2955 | cg2272 | A/G-SPECIFIC ADENINE GLYCOSYLASE. | FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.984 |
mutY | ogt | cg2955 | cg3331 | A/G-SPECIFIC ADENINE GLYCOSYLASE. | METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. | 0.804 |
mutY | radA | cg2955 | cg2950 | A/G-SPECIFIC ADENINE GLYCOSYLASE. | PROBABLE ATP-DEPENDENT PROTEASE, DNA REPAIR (ATP-B; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. | 0.772 |
mutY | recN | cg2955 | cg1602 | A/G-SPECIFIC ADENINE GLYCOSYLASE. | DNA REPAIR PROTEIN RECN; May be involved in recombinational repair of damaged DNA. | 0.764 |
mutY | recO | cg2955 | cg2509 | A/G-SPECIFIC ADENINE GLYCOSYLASE. | Recombinational DNA repair protein (RecF pathway); Involved in DNA repair and RecF pathway recombination. | 0.769 |
mutY | ruvB | cg2955 | cg1869 | A/G-SPECIFIC ADENINE GLYCOSYLASE. | Holliday junction resolvasome helicase subunit; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. | 0.758 |
mutY | uvrB | cg2955 | cg1550 | A/G-SPECIFIC ADENINE GLYCOSYLASE. | EXCINUCLEASE ABC SUBUNIT B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.755 |