node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cgl2772 | pyrE | cg3070 | cg3071 | SPOU RRNA METHYLASE FAMILY PROTEIN. | OROTATE PHOSPHORIBOSYLTRANSFERASE; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.838 |
carA | carB | cg1814 | cg1813 | CARBAMOYL PHOSPHATE SYNTHASE SMALL SUBUNIT; Belongs to the CarA family. | PUTATIVE CARBAMOYL-PHOSPHATE SYNTHASE SUBUNIT. | 0.999 |
carA | pyrB | cg1814 | cg1816 | CARBAMOYL PHOSPHATE SYNTHASE SMALL SUBUNIT; Belongs to the CarA family. | ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
carA | pyrC | cg1814 | cg1815 | CARBAMOYL PHOSPHATE SYNTHASE SMALL SUBUNIT; Belongs to the CarA family. | PUTATIVE DIHYDROOROTASE; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.997 |
carA | pyrD | cg1814 | cg1713 | CARBAMOYL PHOSPHATE SYNTHASE SMALL SUBUNIT; Belongs to the CarA family. | DIHYDROOROTATE DEHYDROGENASE; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.862 |
carA | pyrE | cg1814 | cg3071 | CARBAMOYL PHOSPHATE SYNTHASE SMALL SUBUNIT; Belongs to the CarA family. | OROTATE PHOSPHORIBOSYLTRANSFERASE; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.797 |
carA | pyrF | cg1814 | cg1812 | CARBAMOYL PHOSPHATE SYNTHASE SMALL SUBUNIT; Belongs to the CarA family. | Orotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.978 |
carB | carA | cg1813 | cg1814 | PUTATIVE CARBAMOYL-PHOSPHATE SYNTHASE SUBUNIT. | CARBAMOYL PHOSPHATE SYNTHASE SMALL SUBUNIT; Belongs to the CarA family. | 0.999 |
carB | prsA | cg1813 | cg1075 | PUTATIVE CARBAMOYL-PHOSPHATE SYNTHASE SUBUNIT. | PHOSPHORIBOSYL PYROPHOSPHATE SYNTHASE ISOZYME 2 PR; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.421 |
carB | pyrB | cg1813 | cg1816 | PUTATIVE CARBAMOYL-PHOSPHATE SYNTHASE SUBUNIT. | ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
carB | pyrC | cg1813 | cg1815 | PUTATIVE CARBAMOYL-PHOSPHATE SYNTHASE SUBUNIT. | PUTATIVE DIHYDROOROTASE; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.996 |
carB | pyrD | cg1813 | cg1713 | PUTATIVE CARBAMOYL-PHOSPHATE SYNTHASE SUBUNIT. | DIHYDROOROTATE DEHYDROGENASE; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. | 0.872 |
carB | pyrE | cg1813 | cg3071 | PUTATIVE CARBAMOYL-PHOSPHATE SYNTHASE SUBUNIT. | OROTATE PHOSPHORIBOSYLTRANSFERASE; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.822 |
carB | pyrF | cg1813 | cg1812 | PUTATIVE CARBAMOYL-PHOSPHATE SYNTHASE SUBUNIT. | Orotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.993 |
prsA | carB | cg1075 | cg1813 | PHOSPHORIBOSYL PYROPHOSPHATE SYNTHASE ISOZYME 2 PR; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | PUTATIVE CARBAMOYL-PHOSPHATE SYNTHASE SUBUNIT. | 0.421 |
prsA | pyrE | cg1075 | cg3071 | PHOSPHORIBOSYL PYROPHOSPHATE SYNTHASE ISOZYME 2 PR; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | OROTATE PHOSPHORIBOSYLTRANSFERASE; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.829 |
prsA | thyA | cg1075 | cg0966 | PHOSPHORIBOSYL PYROPHOSPHATE SYNTHASE ISOZYME 2 PR; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | PROBABLE THYMIDYLATE SYNTHASE; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.481 |
pyrB | carA | cg1816 | cg1814 | ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | CARBAMOYL PHOSPHATE SYNTHASE SMALL SUBUNIT; Belongs to the CarA family. | 0.999 |
pyrB | carB | cg1816 | cg1813 | ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | PUTATIVE CARBAMOYL-PHOSPHATE SYNTHASE SUBUNIT. | 0.999 |
pyrB | pyrC | cg1816 | cg1815 | ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | PUTATIVE DIHYDROOROTASE; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.999 |