node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dcd | dut | cg3155 | cg2086 | DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | PROBABLE DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHY; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.923 |
dcd | ndk | cg3155 | cg2603 | DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | NUCLEOSIDE DIPHOSPHATE KINASE; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.923 |
dcd | pyrE | cg3155 | cg3071 | DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | OROTATE PHOSPHORIBOSYLTRANSFERASE; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.716 |
dcd | pyrF | cg3155 | cg1812 | DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Orotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.701 |
dcd | pyrG | cg3155 | cg1606 | DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | CTP SYNTHETASE; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.943 |
dcd | pyrH | cg3155 | cg2218 | DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | UMP-KINASE; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.661 |
dcd | thiL | cg3155 | cg1495 | DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | THIAMINE-MONOPHOSPHATE KINASE; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.593 |
dcd | thyA | cg3155 | cg0966 | DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | PROBABLE THYMIDYLATE SYNTHASE; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.925 |
dcd | tmk | cg3155 | cg0861 | DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | THYMIDYLATE KINASE, PUTATIVE; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.773 |
dcd | udgA2 | cg3155 | cg3154 | DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | UDP-GLUCOSE 6-DEHYDROGENASE. | 0.594 |
dut | dcd | cg2086 | cg3155 | PROBABLE DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHY; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.923 |
dut | ndk | cg2086 | cg2603 | PROBABLE DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHY; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | NUCLEOSIDE DIPHOSPHATE KINASE; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.978 |
dut | thyA | cg2086 | cg0966 | PROBABLE DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHY; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | PROBABLE THYMIDYLATE SYNTHASE; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.979 |
dut | tmk | cg2086 | cg0861 | PROBABLE DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHY; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | THYMIDYLATE KINASE, PUTATIVE; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.935 |
ndk | dcd | cg2603 | cg3155 | NUCLEOSIDE DIPHOSPHATE KINASE; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.923 |
ndk | dut | cg2603 | cg2086 | NUCLEOSIDE DIPHOSPHATE KINASE; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | PROBABLE DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHY; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.978 |
ndk | pyrG | cg2603 | cg1606 | NUCLEOSIDE DIPHOSPHATE KINASE; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | CTP SYNTHETASE; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.950 |
ndk | pyrH | cg2603 | cg2218 | NUCLEOSIDE DIPHOSPHATE KINASE; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | UMP-KINASE; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.941 |
ndk | tmk | cg2603 | cg0861 | NUCLEOSIDE DIPHOSPHATE KINASE; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | THYMIDYLATE KINASE, PUTATIVE; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.919 |
pyrE | dcd | cg3071 | cg3155 | OROTATE PHOSPHORIBOSYLTRANSFERASE; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.716 |