STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
leuD3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (166 aa)    
Predicted Functional Partners:
OQX92531.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 0.999
leuC
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 0.999
OQX92381.1
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.986
OQX92154.1
NADP-dependent isocitrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.936
OQX91363.1
Homoaconitase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
0.855
OQX92006.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.815
OQX90899.1
Type I citrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family.
    
 0.815
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 
 0.812
OQX92361.1
Hypothetical protein; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.
   
  0.751
OQX92161.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.744
Your Current Organism:
candidate division Zixibacteria bacterium 448495
NCBI taxonomy Id: 1970781
Other names: c. division Zixibacteria bacterium 4484_95, candidate division Zixibacteria bacterium 4484_95
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.