| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKU10365.1 | AKU11077.1 | AzCIB_0460 | AzCIB_1172 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage T-protein. | 0.925 |
| AKU10365.1 | AKU12025.1 | AzCIB_0460 | AzCIB_2130 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | 0.594 |
| AKU10365.1 | folD | AzCIB_0460 | AzCIB_0992 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.942 |
| AKU10365.1 | gcvP | AzCIB_0460 | AzCIB_1166 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.517 |
| AKU10365.1 | gcvP-2 | AzCIB_0460 | AzCIB_2633 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.517 |
| AKU10365.1 | glyA | AzCIB_0460 | AzCIB_0885 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.941 |
| AKU10365.1 | purH | AzCIB_0460 | AzCIB_0797 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.422 |
| AKU10365.1 | purN | AzCIB_0460 | AzCIB_3558 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.445 |
| AKU11077.1 | AKU10365.1 | AzCIB_1172 | AzCIB_0460 | Glycine cleavage T-protein. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.925 |
| AKU11077.1 | folD | AzCIB_1172 | AzCIB_0992 | Glycine cleavage T-protein. | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.958 |
| AKU11077.1 | gcvP | AzCIB_1172 | AzCIB_1166 | Glycine cleavage T-protein. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
| AKU11077.1 | gcvP-2 | AzCIB_1172 | AzCIB_2633 | Glycine cleavage T-protein. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
| AKU11077.1 | glyA | AzCIB_1172 | AzCIB_0885 | Glycine cleavage T-protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.983 |
| AKU11077.1 | purH | AzCIB_1172 | AzCIB_0797 | Glycine cleavage T-protein. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.940 |
| AKU11077.1 | purN | AzCIB_1172 | AzCIB_3558 | Glycine cleavage T-protein. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.924 |
| AKU11077.1 | purU | AzCIB_1172 | AzCIB_2150 | Glycine cleavage T-protein. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.914 |
| AKU11077.1 | purU-2 | AzCIB_1172 | AzCIB_4360 | Glycine cleavage T-protein. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.914 |
| AKU12025.1 | AKU10365.1 | AzCIB_2130 | AzCIB_0460 | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.594 |
| AKU12025.1 | folD | AzCIB_2130 | AzCIB_0992 | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.712 |
| AKU12025.1 | gcvP | AzCIB_2130 | AzCIB_1166 | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.997 |
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