| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKU10365.1 | AKU11077.1 | AzCIB_0460 | AzCIB_1172 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage T-protein. | 0.924 |
| AKU10365.1 | AKU12025.1 | AzCIB_0460 | AzCIB_2130 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | 0.534 |
| AKU10365.1 | folD | AzCIB_0460 | AzCIB_0992 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.940 |
| AKU10365.1 | gcvP | AzCIB_0460 | AzCIB_1166 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.949 |
| AKU10365.1 | gcvP-2 | AzCIB_0460 | AzCIB_2633 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.949 |
| AKU10365.1 | glyA | AzCIB_0460 | AzCIB_0885 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.939 |
| AKU10365.1 | purH | AzCIB_0460 | AzCIB_0797 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.408 |
| AKU10365.1 | purN | AzCIB_0460 | AzCIB_3558 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.419 |
| AKU11076.1 | AKU11077.1 | AzCIB_1171 | AzCIB_1172 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Glycine cleavage T-protein. | 0.785 |
| AKU11076.1 | AKU12025.1 | AzCIB_1171 | AzCIB_2130 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Sarcosine oxidase subunit alpha; Belongs to the GcvT family. | 0.610 |
| AKU11076.1 | AKU12028.1 | AzCIB_1171 | AzCIB_2133 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | L-serine dehydratase 1; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.900 |
| AKU11076.1 | gcvP | AzCIB_1171 | AzCIB_1166 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.737 |
| AKU11076.1 | gcvP-2 | AzCIB_1171 | AzCIB_2633 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.640 |
| AKU11076.1 | glyA | AzCIB_1171 | AzCIB_0885 | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.943 |
| AKU11077.1 | AKU10365.1 | AzCIB_1172 | AzCIB_0460 | Glycine cleavage T-protein. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.924 |
| AKU11077.1 | AKU11076.1 | AzCIB_1172 | AzCIB_1171 | Glycine cleavage T-protein. | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.785 |
| AKU11077.1 | folD | AzCIB_1172 | AzCIB_0992 | Glycine cleavage T-protein. | Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.961 |
| AKU11077.1 | gcvP | AzCIB_1172 | AzCIB_1166 | Glycine cleavage T-protein. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
| AKU11077.1 | gcvP-2 | AzCIB_1172 | AzCIB_2633 | Glycine cleavage T-protein. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
| AKU11077.1 | glyA | AzCIB_1172 | AzCIB_0885 | Glycine cleavage T-protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.988 |
