AKU11076.1 protein (Azoarcus sp. CIB) - STRING interaction network

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AKU11076.1

L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (459 aa)

Predicted Functional Partners:

glyA-2

0.972

glyA

0.940

glyA-3

0.940

ilvA

0.925

AKU14255.1

0.925

AKU12096.1

0.910

AKU14254.1

0.910

AKU10728.1

0.906

AKU12667.1

0.906

trpA

0.906

Your Current Organism:

Azoarcus sp. CIB

NCBI taxonomy Id: 198107
Other names: A. sp. CIB

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKU10728.1	AKU11076.1	AzCIB_0823	AzCIB_1171	Serine O-acetyltransferase.	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	0.906
AKU10728.1	AKU12096.1	AzCIB_0823	AzCIB_2201	Serine O-acetyltransferase.	Phosphoserine phosphatase protein.	0.830
AKU10728.1	AKU12667.1	AzCIB_0823	AzCIB_2774	Serine O-acetyltransferase.	O-acetylserine synthase.	0.926
AKU10728.1	AKU14254.1	AzCIB_0823	AzCIB_4361	Serine O-acetyltransferase.	Phosphoserine phosphatase.	0.818
AKU10728.1	AKU14255.1	AzCIB_0823	AzCIB_4362	Serine O-acetyltransferase.	Threonine dehydratase.	0.811
AKU10728.1	glyA	AzCIB_0823	AzCIB_0885	Serine O-acetyltransferase.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.813
AKU10728.1	glyA-2	AzCIB_0823	AzCIB_1169	Serine O-acetyltransferase.	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.813
AKU10728.1	glyA-3	AzCIB_0823	AzCIB_2134	Serine O-acetyltransferase.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.813
AKU10728.1	ilvA	AzCIB_0823	AzCIB_4265	Serine O-acetyltransferase.	Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.	0.811
AKU10728.1	trpA	AzCIB_0823	AzCIB_3035	Serine O-acetyltransferase.	Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.811
AKU11076.1	AKU10728.1	AzCIB_1171	AzCIB_0823	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	Serine O-acetyltransferase.	0.906
AKU11076.1	AKU12096.1	AzCIB_1171	AzCIB_2201	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	Phosphoserine phosphatase protein.	0.910
AKU11076.1	AKU12667.1	AzCIB_1171	AzCIB_2774	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	O-acetylserine synthase.	0.906
AKU11076.1	AKU14254.1	AzCIB_1171	AzCIB_4361	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	Phosphoserine phosphatase.	0.910
AKU11076.1	AKU14255.1	AzCIB_1171	AzCIB_4362	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	Threonine dehydratase.	0.925
AKU11076.1	glyA	AzCIB_1171	AzCIB_0885	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.940
AKU11076.1	glyA-2	AzCIB_1171	AzCIB_1169	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.972
AKU11076.1	glyA-3	AzCIB_1171	AzCIB_2134	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.940
AKU11076.1	ilvA	AzCIB_1171	AzCIB_4265	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.	0.925
AKU11076.1	trpA	AzCIB_1171	AzCIB_3035	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.906