AKU11077.1 protein (Azoarcus sp. CIB) - STRING interaction network

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Score

AKU11077.1

Glycine cleavage T-protein. (376 aa)

Predicted Functional Partners:

gcvH

0.999

gcvP

0.999

gcvH-2

0.999

gcvP-2

0.999

glyA-2

0.991

AKU10887.1

0.988

glyA

0.983

glyA-3

0.983

folD

0.958

AKU11757.1

0.958

Your Current Organism:

Azoarcus sp. CIB

NCBI taxonomy Id: 198107
Other names: A. sp. CIB

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKU10887.1	AKU11077.1	AzCIB_0982	AzCIB_1172	Dihydrolipoamide dehydrogenase.	Glycine cleavage T-protein.	0.988
AKU10887.1	AKU11757.1	AzCIB_0982	AzCIB_1862	Dihydrolipoamide dehydrogenase.	Dihydrolipoamide dehydrogenase.	0.976
AKU10887.1	folD	AzCIB_0982	AzCIB_0992	Dihydrolipoamide dehydrogenase.	Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	0.541
AKU10887.1	gcvH	AzCIB_0982	AzCIB_1165	Dihydrolipoamide dehydrogenase.	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	0.990
AKU10887.1	gcvH-2	AzCIB_0982	AzCIB_2632	Dihydrolipoamide dehydrogenase.	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	0.990
AKU10887.1	gcvP	AzCIB_0982	AzCIB_1166	Dihydrolipoamide dehydrogenase.	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	0.991
AKU10887.1	gcvP-2	AzCIB_0982	AzCIB_2633	Dihydrolipoamide dehydrogenase.	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	0.991
AKU10887.1	glyA	AzCIB_0982	AzCIB_0885	Dihydrolipoamide dehydrogenase.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.866
AKU10887.1	glyA-2	AzCIB_0982	AzCIB_1169	Dihydrolipoamide dehydrogenase.	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.866
AKU10887.1	glyA-3	AzCIB_0982	AzCIB_2134	Dihydrolipoamide dehydrogenase.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.866
AKU11077.1	AKU10887.1	AzCIB_1172	AzCIB_0982	Glycine cleavage T-protein.	Dihydrolipoamide dehydrogenase.	0.988
AKU11077.1	AKU11757.1	AzCIB_1172	AzCIB_1862	Glycine cleavage T-protein.	Dihydrolipoamide dehydrogenase.	0.958
AKU11077.1	folD	AzCIB_1172	AzCIB_0992	Glycine cleavage T-protein.	Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.	0.958
AKU11077.1	gcvH	AzCIB_1172	AzCIB_1165	Glycine cleavage T-protein.	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	0.999
AKU11077.1	gcvH-2	AzCIB_1172	AzCIB_2632	Glycine cleavage T-protein.	Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	0.999
AKU11077.1	gcvP	AzCIB_1172	AzCIB_1166	Glycine cleavage T-protein.	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	0.999
AKU11077.1	gcvP-2	AzCIB_1172	AzCIB_2633	Glycine cleavage T-protein.	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	0.999
AKU11077.1	glyA	AzCIB_1172	AzCIB_0885	Glycine cleavage T-protein.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.983
AKU11077.1	glyA-2	AzCIB_1172	AzCIB_1169	Glycine cleavage T-protein.	Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.991
AKU11077.1	glyA-3	AzCIB_1172	AzCIB_2134	Glycine cleavage T-protein.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.983