Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AKU13500.1uroporphyrinogen-III methylase siroheme synthase; Belongs to the precorrin methyltransferase family. (274 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.988
AKU10697.1
Uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
 0.973
AKU14114.1
Sulfite reductase.
 
  
 0.956
AKU10644.1
uroporphyrin-III C-methyltransferase.
 
 
0.951
AKU14029.1
Precorrin-2 C20-methyltransferase/cobalt-factor II C20-methyltransferase; Methylates precorrin-2 at the C-20 position to produce precorrin-3A.
  
 
 0.949
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
    
 0.948
cysC
Bifunctional enzyme NodQ; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.
  
  
 0.934
AKU14025.1
Sirohydrochlorin cobaltochelatase, cobalamin (vitamin B12) biosynthesis CbiX protein.
 
  
 0.932
AKU14116.1
Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite.
 
  
 0.932
AKU13884.1
Sirohydrochlorin cobaltochelatase, cobalamin (vitamin B12) biosynthesis CbiX protein.
  
  
 0.916
Your Current Organism:
Azoarcus sp. CIB
NCBI taxonomy Id: 198107
Other names: A. sp. CIB
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