ilvA protein (Azoarcus sp. CIB) - STRING interaction network

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ilvA

Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (506 aa)

Predicted Functional Partners:

AKU13419.1

0.967

AKU12941.1

0.963

AKU12793.1

0.960

leuB

0.946

AKU12942.1

0.944

AKU13418.1

0.943

trpB-2

0.937

trpA

0.927

AKU11076.1

0.925

AKU12028.1

0.925

Your Current Organism:

Azoarcus sp. CIB

NCBI taxonomy Id: 198107
Other names: A. sp. CIB

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKU11076.1	AKU12028.1	AzCIB_1171	AzCIB_2133	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	L-serine dehydratase 1; Belongs to the iron-sulfur dependent L-serine dehydratase family.	0.900
AKU11076.1	ilvA	AzCIB_1171	AzCIB_4265	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.	0.925
AKU11076.1	trpA	AzCIB_1171	AzCIB_3035	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.906
AKU11076.1	trpB-2	AzCIB_1171	AzCIB_3036	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	0.900
AKU12028.1	AKU11076.1	AzCIB_2133	AzCIB_1171	L-serine dehydratase 1; Belongs to the iron-sulfur dependent L-serine dehydratase family.	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	0.900
AKU12028.1	ilvA	AzCIB_2133	AzCIB_4265	L-serine dehydratase 1; Belongs to the iron-sulfur dependent L-serine dehydratase family.	Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.	0.925
AKU12028.1	trpA	AzCIB_2133	AzCIB_3035	L-serine dehydratase 1; Belongs to the iron-sulfur dependent L-serine dehydratase family.	Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.906
AKU12028.1	trpB-2	AzCIB_2133	AzCIB_3036	L-serine dehydratase 1; Belongs to the iron-sulfur dependent L-serine dehydratase family.	Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	0.900
AKU12793.1	AKU12941.1	AzCIB_2900	AzCIB_3048	Threonine synthase.	Acetolactate synthase 1 regulatory subunit.	0.597
AKU12793.1	AKU13419.1	AzCIB_2900	AzCIB_3526	Threonine synthase.	Acetolactate synthase 3 regulatory subunit.	0.604
AKU12793.1	ilvA	AzCIB_2900	AzCIB_4265	Threonine synthase.	Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.	0.960
AKU12793.1	leuB	AzCIB_2900	AzCIB_3042	Threonine synthase.	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	0.690
AKU12793.1	trpB-2	AzCIB_2900	AzCIB_3036	Threonine synthase.	Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	0.438
AKU12941.1	AKU12793.1	AzCIB_3048	AzCIB_2900	Acetolactate synthase 1 regulatory subunit.	Threonine synthase.	0.597
AKU12941.1	AKU12942.1	AzCIB_3048	AzCIB_3049	Acetolactate synthase 1 regulatory subunit.	Acetolactate synthase I, large subunit.	0.999
AKU12941.1	AKU13418.1	AzCIB_3048	AzCIB_3525	Acetolactate synthase 1 regulatory subunit.	Acetolactate synthase III, large subunit.	0.993
AKU12941.1	AKU13419.1	AzCIB_3048	AzCIB_3526	Acetolactate synthase 1 regulatory subunit.	Acetolactate synthase 3 regulatory subunit.	0.944
AKU12941.1	ilvA	AzCIB_3048	AzCIB_4265	Acetolactate synthase 1 regulatory subunit.	Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.	0.963
AKU12941.1	leuB	AzCIB_3048	AzCIB_3042	Acetolactate synthase 1 regulatory subunit.	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	0.986
AKU12941.1	trpB-2	AzCIB_3048	AzCIB_3036	Acetolactate synthase 1 regulatory subunit.	Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	0.421

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