Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
hisC-2Histidinol-phosphate aminotransferase; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (455 aa)    
Predicted Functional Partners:
hisB
Imidazoleglycerol-phosphate dehydratase.
 
 0.997
AKU13511.1
Prephenate dehydrogenase.
  
 
 0.974
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.963
AKU13512.1
Chorismate mutase/prephenate dehydratase.
  
 
 0.958
AKU10015.1
Aminotransferase class-IV.
 
 
 0.932
hisI
phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
 
  
 0.918
hisH
Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.917
AKU10676.1
Aromatic amino acid aminotransferase.
   
 
 0.916
AKU12707.1
Aromatic amino acid aminotransferase.
   
 
 0.916
hisF
Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
  
 0.911
Your Current Organism:
Azoarcus sp. CIB
NCBI taxonomy Id: 198107
Other names: A. sp. CIB
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.